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AssigneeRutgers, The State University of New Jersey
InventorsDominik J. Naczynski, Mei-Chee Tan, Richard E. Riman, Charles Roth, Prabhas V. Moghe
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Disclosed is a method of non-invasive infrared imaging, comprising (a) administering a composition containing infrared-emitting particles which contain rare earth elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles; and (b) irradiating with infrared radiation, where both excitation and emission spectra of the encapsulated particles are in the infrared region. Analogous methods of image-guided biomedical intervention, and drug tracking and delivery are also disclosed. Also disclosed is a composition for biomedical applications, containing infrared-emitting particles which contain rare earth-elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles.
A method of non-invasive infrared imaging, comprising the steps of:
A method of improving the biocompatibility and/or reducing the toxicity and/or side effects of a drug and/or imaging agent, or a method of biologically targeting a drug and/or imaging agent, comprising the step of encapsulating said drug and/or imaging agent with a biocompatible matrix.
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A composition for biomedical applications, comprising infrared-emitting particles comprising rare earth-elements that emit in the short-wavelength infrared (SWIR) spectrum, wherein said particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles.
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Dependencies are inferred from the claim text.