US 2014/0193329 A1 · ANTI-CD151 ANTIBODIES AND THEIR USE IN THE TREATMENT OF CANCER

Abstract

The present invention relates to new antibodies capable of binding specifically to the human CD151 protein, especially monoclonal antibodies of murine origin, which are chimeric and humanised, and also to the amino acid and nucleic sequences coding for those antibodies. The invention also includes use of those antibodies as medicaments for the prophylactic and/or therapeutic treatment of cancers and in diagnostic methods or kits for diseases associated with overexpression of the CD151 protein. Finally, the invention includes products and/or compositions comprising such antibodies in association with antibodies and/or anti-cancer agents or conjugated with toxins and/or radioelements and their use in the prevention and/or treatment of certain cancers.

Claims25

Dependent claims

An isolated antibody that is capable of binding to the CD151 protein and comprises:

i) a light chain comprising CDR-L1, CDR-L2, and CDR-L3, wherein:
CDR-L1 is chosen from SEQ ID No. 1 and SEQ ID No. 59;
CDR-L2 is chosen from SEQ ID No. 2 and SEQ ID No. 60;
CDR-L3 is SEQ ID No. 3;
and ii) a heavy chain comprising CDR-H1, CDR-H2 and CDR-H3, wherein CDR-H1 is chosen from SEQ ID No. 4 and SEQ ID No. 61;
CDR-H2 is chosen from SEQ ID No. 5 and SEQ ID No. 62;
CDR-H3 is chosen from SEQ ID No. 6 and SEQ ID No. 63;
or a CD151-binding fragment of said antibody.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/049,617Filed 9 Oct 2013

Priority

FR 080198511 Apr 2008

Published

10 Jul 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07K 16/30
Against receptors, cell surface antigens or cell surface determinants: from tumour cells
A61K 39/39558
Against materials from animals: against tumor tissues, cells, antigens
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61P 35/00
Antineoplastic agents

Family

Application12/576,824Division · filed 9 Oct 2009

Application13/440,259Division · filed 5 Apr 2012

Application14/049,617Division

Application12/576,824Continuation in part

US 2010/0150902 A1Published application

US 2012/0284810 A1Published application

US 8,198,413 B2Related patent

US 8,697,855 B2Related patent

US 2014/0193329 A1This patent

From the US filing history. Foreign family members aren’t listed.

Anti-cd151 antibodies and their use in the treatment of cancer

Life of this patent

Anti-cd151 antibodies and their use in the treatment of cancer

Life of this patent

Abstract

Claims25