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US 2014/0191123 A1Published application
Ion Guide Coupled to MALDI Ion Source
AssigneeMicromass UK Limited
InventorsJason Lee Wildgoose, Steven Derek Pringle, Kevil Giles, Jeffery Mark Brown, Paul Murray, Daniel James Kenny
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Abstract
A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
Claims21
A method of mass spectrometry comprising:
- providing a pulsed ion source;
- energising said ion source one or more times to generate a first group of ions;
- energising said ion source one or more times to generate a second different group of ions;
- simultaneously transmitting both said first group of ions and said second group of ions through a portion or section of a mass spectrometer whilst keeping said first and second groups of ions isolated from each other;
- providing a conjoined ion guide comprising:
- (i) a first ion guide section comprising a plurality of electrodes each having an aperture through which ions are transmitted and wherein a first ion guiding path is formed within the first ion guide section;
- and (ii) a second ion guide section comprising a plurality of electrodes each having an aperture through which ions are transmitted and wherein a second ion guiding path is formed within the second ion guide section, wherein a radial pseudo-potential barrier is formed between the first ion guiding path and the second ion guiding path;
- directing a laser pulse through said first ion guiding path and onto a target to produce an ion beam;
- and
- directing the ion beam away from the optic axis of the incident laser pulse by transmitting said ion beam from said first ion guiding path into said second ion guiding path.
7 more elements
(canceled)
6-10. (canceled)
18-20. (canceled)
22-23. (canceled)
26-35. (canceled)
A mass spectrometer comprising:
- a pulsed ion source;
- a conjoined ion guide comprising:
- (i) a first ion guide section comprising a plurality of electrodes each having an aperture through which ions are transmitted and wherein a first ion guiding path is formed within the first ion guide section;
- and (ii) a second ion guide section comprising a plurality of electrodes each having an aperture through which ions are transmitted and wherein a second ion guiding path is formed within the second ion guide section, wherein a radial pseudo-potential barrier is formed between the first ion guiding path and the second ion guiding path;
- and
- a control system arranged and adapted:
- (i) to energise said ion source one or more times to generate a first group of ions;
- (ii) to energise said ion source one or more times to generate a second different group of ions;
- and
- (iii) to cause both said first group of ions and said second group of ions to be simultaneously transmitted through a portion or section of a mass spectrometer whilst keeping said first and second groups of ions isolated from each other
- (iv) to direct a laser pulse through said first ion guiding path and onto a target to produce an ion beam;
- (v) to direct the ion beam away from the optic axis of the incident laser pulse by transmitting said ion beam from said first ion guiding path into said second ion guiding path.
9 more elements
37-70. (canceled)
Dependencies are inferred from the claim text.