US 2014/0190890 A1 · COLLECTION SYSTEM FOR PURIFICATION FLOWSTREAMS

Abstract

A collection system for collecting samples from a flowstream (5) exiting a supercritical fluid chromatography system is provided. The collection system comprises: (i) a first back pressure regulator (10) on the flowstream as it exits the chromatography system, (ii) a gas-liquid separator (30) having a tapered and angled dripper (65), which introduces the flow into the separator at an angle tangential to the separator wall; and (iii) one or more fraction collectors (15), wherein the fraction collector is at a reduced pressure collection point, between 100 bar and atmospheric pressure. A collection system for HPLC is also provided, as well as a process for collection of samples from a flowstream.

Claims9

Dependent claims

A process for collecting samples in a flow stream from a supercritical fluid chromatography system, the flowstream having gas and liquid components, the process comprising the steps of:

i) reducing the pressure of the flow stream to a pressure between system pressure and atmospheric pressure;
ii) optionally, heating the flow stream;
iii) separating the gas and liquid components in a separator having a tapered and angled dripper which introduces the flow to the separator at an angle tangential to the separator wall;
and
iv) collecting the samples in collection vessels which are at a pressure between atmospheric pressure up to a pressure below system pressure.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/085,387Filed 20 Nov 2013

Priority

12 Nov 2008

Published

10 Jul 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

B01D 15/10
Selective adsorption, e.g. chromatography: characterised by constructional or operational features
G01N 30/82
Fraction collectors: automatic means therefor
G01N 30/02
Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g.…:…
G01N 2030/324
Of pressure or speed: speed, flow rate

Family

Application61/199,026Us provisional application · filed 12 Nov 2008

Application13/063,571Division · filed 17 Jun 2011

Application14/085,387Division

US 2013/0186831 A1Published application

US 9,205,350 B2Related patent

US 9,205,351 B2Related patent

US 2014/0190890 A1This patent

From the US filing history. Foreign family members aren’t listed.

Collection system for purification flowstreams

Life of this patent

Collection system for purification flowstreams

Life of this patent

Abstract

Claims9