Extrusion methods and devices for drug delivery
AssigneePresage Biosciences, Inc.
InventorsEdward Gallagher, Alicia Moreno-Gonzelez, Worm Lund, SR., Worm Lund, JR., Marc Grenley
Life of this patent
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Abstract
Disclosed herein are devices and methods for delivering agents to a solid tissue.
Claims33
-135. (canceled)
A device, comprising a top block comprising a first plurality of holes sized to allow a needle to pass through said top block and a bottom block comprising a second plurality of holes sized to allow a needle to pass through said bottom block, wherein said top and bottom blocks are in a substantially parallel arrangement and wherein said first and second plurality of holes are positioned so as to allow one or more needles to pass through a hole in said top block and said bottom block in a path substantially vertical to a plane of both blocks.
A method of operating a device, comprising:
- a. providing a device comprising a top block comprising a first plurality of holes sized to allow a needle to pass through said top block and a bottom block comprising a second plurality of holes sized to allow a needle to pass through said bottom block, wherein said top and bottom blocks are in a substantially parallel arrangement and wherein said first and second plurality of holes are positioned so as to allow one or more needles to pass through a hole in said top block and said bottom block in a path substantially vertical to a plane of both blocks
- b. inserting one or more needles through said top block and said bottom block into a solid tissue, wherein at least one needle has a control attachment;
- c. simultaneously moving said top block away from said bottom block;
- and
- d. injecting at least one agent into said solid tissue.
A device for delivering an agent to a solid tissue, comprising:
- a. two or more needles, wherein said two or more needles comprises a first end and a second end;
- b. a reservoir, wherein said reservoir is in fluid communication with said first end of said two or more needles;
- c. a plunger, wherein said plunger is coupled to said reservoir;
- and
- d. a controller, wherein said controller controls a rate of fluid delivery when said two or more needles are withdrawn from said solid tissue.
A method of delivering an agent to a solid tissue of a subject, comprising:
- a. inserting a plurality of needles into said solid tissue;
- and
- b. delivering said agent to said solid tissue, wherein a rate of delivery of said agent is substantially controlled by a rate of needle withdrawal from said solid tissue.
Dependencies are inferred from the claim text.