US 2014/0155731 A1 · METHOD FOR IDENTIFYING NEUROPROTECTIVE COMPOUNDS AND/OR NEUROREGENERATION STIMULATORS BY FRACTIONAL ANISOTROPY MEASUREMENTS BY DIFFUSION-BASED MRI SCANNING

Abstract

The present invention relates to a method for monitoring the effectiveness of a treatment on neuroprotection and to a method for identifying candidate molecules that are neuroprotectors and/or neuronal growth stimulators. The present invention can be used, in particular, in the field of pharmaceutics, in the field of scientific research and in the field of clinical trials and validation of therapeutic substances.

Claims13

Dependent claims

A method for monitoring the effectiveness of a treatment on neuroprotection comprising:

a) measurement of the fractional anisotropy FA1 in at least one region of interest of the brain on an image obtained by Magnetic Resonance Imaging (MRI) of the brain of a patient before said treatment,
b) measurement of the fractional anisotropy FA2 of said at least one region of interest of the brain on an MRI imaging of the brain of said patient after said treatment,
c) comparison of the fractional anisotropy values and calculation of a score (S) according to the following formula:
S=FA2/FA1,
a value of S greater than 1.08 indicating that the treatment is a neuroprotective and/or neural growth stimulator treatment.

2 more elements

A method for identifying a neuroprotective and/or neural growth stimulative candidate molecule comprising:

a) measurement of the fractional anisotropy FA1 in at least one region of interest of the brain on an image obtained by Magnetic Resonance Imaging (MRI) of the brain of a patient before said treatment,
b) measurement of the fractional anisotropy FA2 of said at least one region of interest of the brain on an MRI imaging of the brain of said patient after said treatment,
c) comparison of the fractional anisotropy values and calculation of a score (S) according to the following formula:
S=FA2/FA1,
a value of S greater than or equal to 1.08 indicating that the candidate molecule is neuroprotective and/or neural growth stimulative.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/119,226Filed 23 May 2012

Priority

FR 115446923 May 2011

Published

5 Jun 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61B 5/4848
Other medical applications: monitoring or testing the effects of treatment, e.g. of medication
A61B 5/0042
Adapted for image acquisition of a particular organ or body part: for the brain
A61B 5/055
Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves:…
A61B 5/7225
Signal processing specially adapted for physiological signals or for diagnostic purposes: details of analogue processing, e.g. isolation…

Method for identifying neuroprotective compounds and/or neuroregeneration stimulators by fractional anisotropy measurements by diffusion-based mri scanning

Life of this patent

Method for identifying neuroprotective compounds and/or neuroregeneration stimulators by fractional anisotropy measurements by diffusion-based mri scanning

Life of this patent

Abstract

Claims13