Methods and systems that monitor for an impending myocardial infarction

For use with a chronically implanted device, a method for monitoring for an impending myocardial infarction (MI), comprising:

• (a) obtaining
• a first signal indicative of changes arterial volume, the first signal comprising one of a photoplethysmography (PPG) signal and an impedance-plethysmography (IPG) signal, and
• a second signal indicative of electrical cardiac activity, the second signal comprising one of an electrocardiogram (ECG) signal and an intracardiac electrogram (IEGM) signal;
• (b) determining, based on the first and second signals, a metric indicative of aortic pulse wave velocity (PWV);
• (c) determining, based on the first signal, a metric indicative of diastolic blood pressure (DBP);
• (d) determining, based on at least one of the first and second signals, a metric indicative of heart rate (HR);
• (a) determining, based on the first signal, a metric indicative of vascular stiffness (VS);
• (f) monitoring for an impending MI based on the metrics indicative of PWV, DBP, HR and VS;
• and
• (g) triggering an alert and/or therapy in response to an impending MI being detected at step (f).