Method for increased uptake of beneficial agent and ejection fraction by postconditioning procedures

A catheter system comprising:

• a catheter comprising an expandable member, an inflation lumen, and an independent deflation lumen;
• a handle capable of hand-carrying comprising
• a reservoir disposed entirely within the handle for supplying fluid to inflate the expandable member;
• an actuator disposed on the handle and capable of inflating the expandable member via the inflation lumen and deflating the expandable member via the deflation lumen;
• and
• a valve for controlling fluid flow in one direction through the catheter.

A catheter system comprising:

• a catheter comprising an expandable member, an inflation lumen, and an independent deflation lumen;
• a handle capable of hand-carrying comprising
• a reservoir disposed entirely within the handle for supplying fluid to inflate the expandable member;
• an actuator disposed on the handle and defining a first and second position, the actuator capable of inflating the expandable member via the inflation lumen in the first position and deflating the expandable member via the deflation lumen in the second position;
• and
• a valve for modulating fluid flow in one direction defining a fluid circuit through the catheter from said reservoir to said inflation lumen to said expandable member to said deflation lumen.