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AssigneeThe Johns Hopkins University
InventorsJing Zeng, Charles George Drake, Drew M. Pardoll, Michael Lim
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An approach combining immune-based therapies with focused radiation, including stereotactic radiation, to treat cancers is disclosed. The use of focused radiation primes the immune system in a similar manner to vaccines to augment immune-based therapies and can counteract the suppressive effects of a tumor. The combination of focused radiation and immune-based therapies, including administration of at least one immunotherapeutic agent, improves survival compared to each therapy alone and can, in some cases, lead to a durable cure. Accordingly, focused radiation can be an adjuvant for immune-based therapies for treating cancers.
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A method for treating a tumor in a subject in need of treatment thereof, the method comprising administering to the subject a therapeutically effective dose of focused radiation to treat the tumor in combination with at least one immunotherapeutic agent.
A method of neoadjuvant therapy for treating cancer in a subject in need of treatment thereof, the method comprising:
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