Resorcylic acid lactone compounds
AssigneeKorea Institute of Science and Technology
InventorsTae Bo SIM, Ho Jong Yoon, Ji Nyeo Kim
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Abstract
Disclosed are a novel resorcyclic acid lactone compound with inhibitory activity against protein kinases, a pharmaceutically acceptable salt thereof, a method for the synthesis thereof, and a pharmaceutical composition for the treatment and prevention of various cancer diseases comprising the same as an active ingredient. The novel resorcyclic acid lactone compound is useful as a therapeutic for cancer diseases, especially blood cancer, inter alia, acute myeloid leukemia (AML).
Claims13
A compound, selected from among a resorcyclic acid lactone compound represented by the following Chemical Formula F, and a pharmaceutically acceptable salt thereof:
- (wherein R1, R2, R3, and R4 independently represent a hydrogen atom or C1˜C10 alkyl).
A method for synthesizing a resorcyclic acid lactone compound, as illustrated in the following Reaction Scheme, comprising:
- converting compound into a lactam compound through hydrolysis and Mitsunobu reaction;
- removing p-methoxybenzyl (PMB) from the compound by deprotection to give an alcohol compound;
- oxidizing compound into an α,β-unsaturated ketone compound in presence of Dess-Martin periodinane and a base;
- performing a deprotection reaction to remove methoxymethyl (MOM) from compound to afford resorcyclic acid lactone compound.
- (wherein R1, R2, R3, and R4 independently represent a hydrogen atom or C1˜C10 alkyl, MOM represents methoxymethyl, and PMB represents p-methoxybenzyl)
Dependencies are inferred from the claim text.