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US 2014/0155627 A1Published application
Process for Forming Amorphous Atorvastatin
AssigneePfizer Inc.
InventorsAntone John deBettencourt, III, Peter Robert Rose, Evgenyi Shalaev, George Joseph Quallich, Carl Bernard Ziegler
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Abstract
A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.
Claims15
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The process for forming amorphous atorvastatin comprising:
- (a) dissolving atorvastatin and an antioxidant in a hydroxylic solvent;
- and
- (b) lyophilizing the solution to afford said amorphous atorvastatin.
Dependencies are inferred from the claim text.