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US 2014/0155610 A1Published application
Preparation of pyridonecarboxylic acid antibacterials
AssigneeAbbVie Inc.
InventorsAnthony HAIGHT, David M. BARNES, Geoff G.Z. ZHANG
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Abstract
A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed.
Claims1
A process for making ethyl
- 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxy)azetidin-l-yl)-4-oxo-1,4-di hydroquinoline-3-carboxylate, or a salt thereof, comprising:
- (a) reacting ethyl
- (2E/Z)-3-((6-amino-3,5-difluoropyridin-2-yl)amino)-2-(2,4,5-trifluorobenzoyl)-2-propenoate, or a salt thereof, lithium chloride and 1,8-diazabicyclo[5.4.0]undec-7-ene and not isolating the product;
- (b) reacting the product of step (a), 3-azetidinol hydrochloride and 1,8-diazabicyclo[5.4.0]undec-7-ene and not isolating the product;
- and
- (c) reacting the product of step (b) and isobutyric anhydride and isolating or not isolating the product.
3 more elements
Dependencies are inferred from the claim text.