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US 2014/0155608 A1Published application
Method for the manufacturing of naltrexone
AssigneeH. Lundbeck A/S
InventorsCarla De Faveri, Mariano Stivanello, Florian Anton Martin Huber
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Abstract
The present invention relates to a new process for producing naltrexone [17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-morphinan-6-one] from noroxymorphone [4,5-α-epoxy-3,14-dihydroxy-morphinan-6-one] by alkylation with a cyclopropylmethyl halide.
Claims21
A process for the manufacturing of naltrexone, comprising reacting noroxymorphone with cyclopropylmethyl halide in the presence of N-methyl-2-pyrrolidone and water, wherein the total amount of water compared to noroxymorphone is from 0.4 to 4.0 equivalents.
Dependencies are inferred from the claim text.