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US 2014/0155606 A1Published application
Quinazoline based egfr inhibitors containing a zinc binding moiety
AssigneeCuris, Inc.
InventorsChanggeng Qian, Xiong Cai, Stephen Gould
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Abstract
The present invention relates to quinazoline containing zinc-binding moiety based derivatives of Formula (I) below. These compounds have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and are useful in the treatment of EGFR-TK related diseases and disorders such as cancer. These compounds may further act as HDAC inhibitors.
Claims1
A compound represented by formula I:
- or a pharmaceutically acceptable salt, wherein
- X is O, S, CH2, or —CONH—;
- B is a C3 to C9 alkylene;
- R1 is selected from hydrogen, C1 to C4 alkoxy or substituted C1 to C4 alkoxy;
- R2 is each independently selected from halogen, C1 to C4 alkyl, C2 to C4 alkenyl, and C2 to C4 alkynyl;
- and
- n is 1, 2 or 3.
4 more elements
Dependencies are inferred from the claim text.