Phosphoinositide 3-kinase inhibitors with a zinc binding moiety

A compound of claim 1 represented by formula XXIV:

• wherein:
• G1 is O;
• G4 is S;
• R8 is independently hydrogen, acyl, aliphatic or substituted aliphatic;
• each R1 and R2 is independently selected from absent, hydrogen, hydroxy, amino, halogen, alkoxy, alkylamino, dialkylamino, CF3, CN, NO2, sulfonyl, acyl, aliphatic, substituted aliphatic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, and substituted heterocyclic;
• p is 0, 1 or 2;
• w is 0, 1, 2 or 3;
• n is 0, 1, 2 or 3;
• u is 0, 1, 2, 3, 4, 5, 6, 7 or 8;
• G5 is —N(R8)—C1-C4 alkyl;
• G2 is optionally substituted phenyl, pyridyl, pyrimidyl, indolyl, indazolyl, pyridopyrrolyl, pyrrolyl, pyrazolyl, or benzimidazolyl;
• and
• each R6 is selected from absent, hydrogen, hydroxy, amino, halogen, alkoxy, alkylamino, dialkylamino, CF3, CN, NO2, sulfonyl, acyl, aliphatic, substituted aliphatic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, and substituted heterocyclic.