[1,2,4]Triazolo[1,5-a]Pyridine and [1,2,4]Triazolo[1,5-c]Pyrimidine Compounds and Their Use

A compound selected from compounds of the following formula, and pharmaceutically acceptable salts thereof:

• wherein:
• —X═ is independently —CR6═ or —N═;
• and wherein:
• if —X═ is —CR6═, then:
• —R5 is independently —R5A;
• —R6 is independently —R6A;
• —R7 is independently —R7A;
• —R8 is independently —R8A;
• and
• —W is independently —WA;
• wherein:
• —R5A is independently -Q5A;
• —R6A is independently —H or -Q6A;
• —R7A is independently —H or -Q7A;
• —R8A is independently —H or -Q8A;
• and
• —WA is independently —C(═O)RWA2;
• if —X═ is —N═, then:
• —R5 is independently —R5B;
• —R7 is independently —R7B;
• —R8 is independently —R8B;
• and
• —W is independently —WB;
• wherein:
• —R5B is independently -Q5B;
• —R7B is independently —H or -Q7B;
• —R8B is independently —H or -Q8B;
• and
• —WB is independently —C(═O)RWB2;
• wherein:
• —RWA2 is independently:
• —R1A1, —R1A2, —R1A3, —R1A4, —R1A5, —R1A6, —R1A7, —R1A8,
• -L1A-R1A4, -L1A-R1A5, -L1A-R1A6, -L1A-R1A7, or -L1A-R1A8;
• —RWB2 is independently:
• —R1A2, —R1A3, —R1A4, —R1A5, —R1A6, —R1A7, —R1A8,
• -L1A-R1A4, -L1A-R1A5, -L1A-R1A6, -L1A-R1A7, or -L1A-R1A8;
• wherein:
• each —R1A1 is independently saturated aliphatic C1-6alkyl;
• each —R1A2 is independently aliphatic C2-6alkenyl;
• each —R1A3 is independently aliphatic C2-6alkynyl;
• each —R1A4 is independently saturated C3-6cycloalkyl;
• each —R1A5 is independently C3-6cycloalkenyl;
• each —R1A6 is independently non-aromatic C3-8heterocyclyl;
• each —R1A7 is independently C6-10carboaryl;
• each —R1A8 is independently C5-10heteroaryl;
• each -L1A- is independently saturated aliphatic C1-3alkylene;
• wherein:
• each —R1A4, —R1A5, —R1A6, —R1A7, and —R1A8 is optionally substituted, for example, with one or more substituents —R1B1 and/or one or more substituents —R1B2, and
• each —R1A1, —R1A2, —R1A3, and -L1A- is optionally substituted, for example, with one or more substituents —R1B2,
• wherein:
• each —R1B1 is independently:
• —R1A1, —R1D2, —R1D3, —R1D5, —R1D6, —R1D7, —R1D8,
• -L1D-R1D4, -L1D-R1D5, -L1D-R1D6, -L1D-R1D7, or -L1D-R1D8,
• each —R1B2 is independently:
• —F, —Cl, —Br, —I,
• —CF3, —OCF3,
• —OH, -L1C-OH, —O-L1C-OH,
• —OR1C1, -L1C-OR1C1, —O-L1C-OR1C1,
• —SH, —SR1C1,
• —CN,
• —NO2,
• —NH2, —NHR1C1, —NR1C12, —NR1C2R1C3,
• -L1C-NH2, L1C-NHR1C1, -L1C-NR1C12, -L1C-NR1C2R1C3,
• —O-L1C-NH2, —O-L1C-NHR1C1, —O-L1C-NR1C12, —O-L1C-NR1C2R1C3,
• —C(═O)OH, —C(═O)OR1C1,
• —C(═O)R1C1,
• —C(═O)NH2, —C(═O)NHR1C1, —C(═O)NR1C12, —C(═O)NR1C2R1C3,
• —NHC(═O)R1C1, —NR1C1C(═O)R1C1,
• —NHC(═O)OR1C1, —NR1C1C(═O)OR1C1,
• —OC(═O)NH2, —OC(═O)NHR1C1, —OC(═O)NR1C12, —OC(═O)NR1C2R1C3,
• —NHC(═O)NH2, —NHC(═O)NHR1C1,
• —NHC(═O)NR1C12, —NHC(═O)NR1C2R1C3,
• —NR1C1C(═O)NH2, —NR1C1C(═O)NHR1C1,
• —NR1C1C(═O)NR1C12, —NR1C1C(═O)NR1C2R1C3,
• —NHS(═O)2R1C1, —NR1C1S(═O)2R1C1,
• —S(═O)2NH2, —S(═O)2NHR1C1, —S(═O)2NR1C12, —S(═O)2NR1C2R1C3,
• —S(═O)R1C1, —S(═O)2R1C1, —OS(═O)2R1C1, or —S(═O)2OR1C1;
• wherein:
• each -L1C- is independently saturated aliphatic C1-5alkylene;
• in each group —NR1C2R1C3, R1C2 and R1C3, taken together with the nitrogen atom to which they are attached, form a 4-, 5-, 6-, or 7-membered non-aromatic ring having exactly 1 ring heteroatom or exactly 2 ring heteroatoms, wherein one of said exactly 2 ring heteroatoms is N, and the other of said exactly 2 ring heteroatoms is independently N or O;
• each —R1C1 is independently:
• —R1D1, —R1D2, —R1D3, —R1D4, —R1D5, —R1D6, —R1D7, —R1D8,
• -L1D-R1D4, -L1D-R1D5, -L1D-R1D6, -L1D-R1D7, or -L1D-R1D8;
• each —R1D1 is independently saturated aliphatic C1-6alkyl;
• each —R1D2 is independently aliphatic C2-6alkenyl;
• each —R1D3 is independently aliphatic C2-6alkynyl;
• each —R1D4 is independently saturated C3-6cycloalkyl;
• each —R1D5 is independently C3-6cycloalkenyl;
• each —R1D6 is independently non-aromatic C3-8heterocyclyl;
• each —R1D7 is independently C6-10carboaryl;
• each —R1D8 is independently C5-10heteroaryl;
• each -L1D- is independently saturated aliphatic C1-3alkylene;
• wherein:
• each —R1D4, —R1D5, —R1D6, —R1D7, and —R1D8 is optionally substituted, for example, with one or more substituents —R1E1 and/or one or more substituents —R1E2,
• each —R1D1, R1D2, —R1D3, and -L1D- is optionally substituted, for example, with one or more substituents —R1E2, and
• wherein:
• each —R1E1 is independently saturated aliphatic C1-4alkyl, phenyl, or benzyl;
• each —R1E2 is independently:
• —F, —Cl, —Br, —I,
• —CF3, —OCF3,
• —OH, -L1F-OH, —O-L1F-OH,
• OR1F1, L1F-OR1F1, —O-L1F-OR1F1,
• —SH, —SR1F1,
• —CN,
• —NO2,
• —NH2, —NHR1F1, —NR1D12, —NR1F2R1F3,
• -L1F-NH2, -L1F-NHR1F1, -L1F-NR1F12, -L1F-NR1F2R1F3,
• —C(═O)OH, —C(═O)OR1F1,
• —C(═O)NH2, —C(═O)NHR1F1, —C(═O)NR1F12, or —C(═O)NR1F2R1F3;
• wherein:
• each —R1F1 is independently saturated aliphatic C1-4alkyl, phenyl, or benzyl;
• each -L1F- is independently saturated aliphatic C1-5alkylene;
• and
• in each group —NR1F2R1F3, R1F2 and R1F3, taken together with the nitrogen atom to which they are attached, form a 4-, 5-, 6-, or 7-membered non-aromatic ring having exactly 1 ring heteroatom or exactly 2 ring heteroatoms, wherein one of said exactly 2 ring heteroatoms is N, and the other of said exactly 2 ring heteroatoms is independently N or O;
• -Q5A is independently:
• —R2A1, —R2A2, —R2A3, —R2A4, —R2A5, —R2A6, —R2A7, —R2A8,
• -L2A-R2A4, -L2A-R2A5, -L2A-R2A6, -L2A-R2A7, -L2A-R1A8,
• —F, —Cl, —Br, —I,
• —CF3, —OCF3,
• —OH, -L2C-OH, —O-L2C-OH,
• -L2C-OR2C1, —O-L2C-OR2C1,
• —O—R2D4, —O—R2D6, —O—R2D7, —O—R2D8,
• —O-L2D-R2D4, —O-L2D-R2D6, —O-L2D-R2D7, —O-L2D-R2D8,
• —SH, —SR2C1,
• —CN,
• —NO2,
• —NH2, —NHR2C1, —NR2C12, —NR2C2R2C3,
• -L2C-NH2, -L2C-NHR2C1, —O-L2C-NR2C12, -L2C-NR2C2R2C3,
• —O-L2C-NH2, —O-L2C-NHR2C1, —O-L2C-NR2C12, —O-L2C-NR2C2R2C3,
• —C(═O)OH, —C(═O)OR2C1,
• —C(═O)R2C1,
• —C(═O)NH2, —C(═O)NHR2C1, —C(═O)NR2C12, —C(═O)NR2C2R2C3,
• —NHC(═O)R2C1, —NR2C1C(═O)R2C1,
• —NHC(═O)OR2C1, —NR2C1C(═O)OR2C1,
• —OC(═O)NH2, —OC(═O)NHR2C1, —OC(═O)NR2C12, —OC(═O)NR2C2R2C3,
• —NHC(═O)NH2, —NHC(═O)NHR2C1,
• —NHC(═O)NR2C12, —NHC(═O)NR2C2R2C3,
• —NR2C1C(═O)NH2, —NR2C1C(═O)NHR2C1,
• —NR2C1C(═O)NR1C12, —NR2C1C(═O)NR2C2R2C3,
• —NHS(═O)2R2C1, —NR1C1S(═O)2R2C1,
• —S(═O)2NH2, —S(═O)2NHR2C1, —S(═O)2NR2C12, —S(═O)2NR2C2R2C3,
• —S(═O)R2C1, —S(═O)2R2C1, —OS(═O)2R2C1, or —S(═O)2OR2C1;
• -Q8A is independently:
• —R2A1, —R2A2, —R2A3, —R2A4, —R2A5, —R2A6, —R2A7, —R2A8,
• -L2A-R2A4, -L2A-R2A5, -L2A-R2A6, -L2A-R2A7, -L2A-R1A8,
• —F, —Cl, —Br, —I,
• —CF3, —OCF3,
• —OH, -L2C-OH, —O-L2C-OH,
• -L2C-OR2C1, —O-L2C-OR2C1,
• —SH, —SR2C1,
• —NO2,
• —NH2, —NHR2C1, —NR2C12, —NR2C1R2C3,
• -L2C-NH2, -L2C-NHR2C1, -L2C-NR2C12, -L2C-NR2C2R2C3,
• —O-L2C-NH2, —O-L2C-NHR2C1, —O-L2C-NR2C12, —O-L2C-NR2C2R2C3,
• —C(═O)R2C1,
• —C(═O)NH2, —C(═O)NHR2C1, —C(═O)NR2C12, —C(═O)NR2C2R2C3,
• —NHC(═O)R2C1, —NR2C1C(═O)R2C1,
• —NHC(═O)OR2C1, —NR2C1C(═O)OR2C1,
• —OC(═O)NH2, —OC(═O)NHR2C1, —OC(═O)NR2C12, —OC(═O)NHR2C1R2C3,
• —NHC(═O)NH2, —NHC(═O)NHR2C1,
• —NHC(═O)NR2C12, —NHC(═O)NR2C2R2C3,
• —NR2C1C(═O)NH2, —NR2C1C(═O)NHR2C1,
• —NR2C1C(═O)NR1C12, —NR2C1C(═O)NR2C2R2C3,
• —NHS(═O)2R2C1, —NR1C1S(═O)2R2C1,
• —S(═O)2NH2, —S(═O)2NHR2C1, —S(═O)2NR2C12, —S(═O)2NR2C2R2C3,
• —S(═O)R2C1, —S(═O)2R2C1, —OS(═O)2R2C1, or —S(═O)2OR2C1;
• -Q5B is independently:
• —R2A2, —R2A3, —R2A4, —R2A5, —R2A6, —R2A7, —R2A8,
• -L2A-R2A4, -L2A-R2A5, -L2A-R2A6, -L2A-R2A7, -L2A-R1A8,
• —F, —Cl, —Br, —I,
• —CF3, —OCF3,
• —OH, -L2C-OH, —O-L2C-OH,
• —OR2C1, -L2C-OR2C1, —O-L2C-OR2C1,
• —SH, —SR2C1,
• —CN,
• —NO2,
• —NH2, —NHR2C1, —NR2C12, —NR2C2R2C3,
• -L2C-NH2, -L2C-NHR2C1, -L2C-NR2C12, -L2C-NR2C2R2C3,
• —O-L2C-NH2, —O-L2C-NHR2C1, —O-L2C-NR2C12, —O-L2C-NR2C2R2C3,
• —C(═O)OH, —C(═O)OR2C1,
• —C(═O)R2C1,
• —C(═O)NH2, —C(═O)NHR2C1, —C(═O)NR2C12, —C(═O)NR2C2R2C3,
• —NHC(═O)R2C1, —NR2C1C(═O)R2C1,
• —NHC(═O)OR2C1, —NR2C1C(═O)OR2C1,
• —OC(═O)NH2, —OC(═O)NHR2C1, —OC(═O)NR2C12, —OC(═O)NR2C2R2C3,
• —NHC(═O)NH2, —NHC(═O)NHR2C1,
• —NHC(═O)NR2C12, —NHC(═O)NR2C2R2C3,
• —NR2C1C(═O)NH2, —NR2C1C(═O)NHR2C1,
• —NR2C1C(═O)NR1C12, —NR2C1C(═O)NR2C2R2C3,
• —NHS(═O)2R2C1, —NR1C1S(═O)2R2C1,
• —S(═O)2NH2, —S(═O)2NHR2C1, —S(═O)2NR2C12, —S(═O)2NR2C2R2C3,
• —S(═O)R2C1, —S(═O)2R2C1, —OS(═O)2R2C1, or —S(═O)2OR2C1;
• -Q8B is independently:
• —R2A1, —R2A2, —R2A3, —R2A4, —R2A5, —R2A6, —R2A7, —R2A8,
• -L2A-R2A4, -L2A-R2A5, -L2A-R2A6, -L2A-R2A7, -L2A-R1A8,
• —F, —Cl, —Br, —I,
• —CF3, —OCF3,
• —OH, -L2C-OH, —O-L2C-OH,
• —OR2C1, -L2C-OR2C1, —O-L2C-OR2C1,
• —SH, —SR2C1,
• —CN,
• —NO2,
• —NH2, —NHR2C1, —NR2C12, —NR2C2R2C3,
• -L2C-NH2, -L2C-NHR2C1, -L2C-NR2C12, -L2C-NR2C2R2C3,
• —O-L2C-NH2, —O-L2C-NHR2C1, —O-L2C-NR2C12, —O-L2C-NR2C2R2C3,
• —C(═O)OH, —C(═O)OR2C1,
• —C(═O)R2C1,
• —C(═O)NH2, —C(═O)NHR2C1, —C(═O)NR2C12, —C(═O)NR2C2R2C3,
• —NHC(═O)R2C1, —NR2C1C(═O)R2C1,
• —NHC(═O)OR2C1, —NR2C1C(═O)OR2C1,
• —OC(═O)NH2, —OC(═O)NHR2C1, —OC(═O)NR2C12, —OC(═O)NR2C2R2C3,
• —NHC(═O)NH2, —NHC(═O)NHR2C1,
• —NHC(═O)NR2C12, —NHC(═O)NR2C2R2C3,
• —NR2C1C(═O)NH2, —NR2C1C(═O)NHR2C1,
• —NR2C1C(═O)NR1C12, —NR2C1C(═O)NR2C2R2C3,
• —NHS(═O)2R2C1, —NR1C1S(═O)2R2C1,
• —S(═O)2NH2, —S(═O)2NHR2C1, —S(═O)2NR2C12, —S(═O)2NR2C2R2C3,
• —S(═O)R2C1, —S(═O)2R2C1, —OS(═O)2R2C1, or —S(═O)2OR2C1;
• each of -Q6A, -Q7A, and -Q7B is independently:
• —R2A1, —R2A2, —R2A3, —R2A4, —R2A5, —R2A6, —R2A7, —R2A8,
• -L2A-R2A4, -L2A-R2A5, -L2A-R2A6, -L2A-R2A7, -L2A-R1A8,
• —F, —Cl, —Br, —I,
• —CF3, —OCF3,
• —OH, -L2C-OH, —O-L2C-OH,
• —OR2C1, -L2C-OR2C1, —O-L2C-OR2C1,
• —SH, —SR2C1,
• —CN,
• —NO2,
• —NH2, —NHR2C1, —NR2C12, —NR2C2R2C3,
• -L2C-NH2, -L2C-NHR2C1, -L2C-NR2C12, -L2C-NR2C2R2C3,
• —O-L2C-NH2, -L2C-NHR2C1, —O-L2C-NR2C12, —O-L2C-NR2C2R2C3,
• —C(═O)OH, —C(═O)OR2C1,
• —C(═O)R2C1,
• —C(═O)NH2, —C(═O)NHR2C1, —C(═O)NR2C12, —C(═O)NR2C2R2C3,
• —NHC(═O)R2C1, —NR2C1C(═O)R2C1,
• —NHC(═O)OR2C1, —NR2C1C(═O)OR2C1,
• —OC(═O)NH2, —OC(═O)NHR2C1, —OC(═O)NR2C12, —OC(═O)NR2C2R2C3,
• —NHC(═O)NH2, —NHC(═O)NHR2C1,
• —NHC(═O)NR2C12, —NHC(═O)NR2C2R2C3,
• —NR2C1C(═O)NH2, —NR2C1C(═O)NHR2C1,
• —NR2C1C(═O)NR1C12, —NR2C1C(═O)NR2C2R2C3,
• —NHS(═O)2R2C1, —NR1C1S(═O)2R2C1,
• —S(═O)2NH2, —S(═O)2NHR2C1, —S(═O)2NR2C12, —S(═O)2NR2C2R2C3,
• —S(═O)R2C1, —S(═O)2R2C1, —OS(═O)2R2C1, or —S(═O)2OR2C1;
• wherein:
• each —R2A1 is independently saturated aliphatic C1-6alkyl;
• each —R2A2 is independently aliphatic C2-6alkenyl;
• each —R2A3 is independently aliphatic C2-6alkynyl;
• each —R2A4 is independently saturated C3-6cycloalkyl;
• each —R2A5 is independently C3-6cycloalkenyl;
• each —R2A6 is independently non-aromatic C3-8heterocyclyl;
• each —R2A7 is independently C6-10carboaryl;
• each —R2A8 is independently C5-10heteroaryl;
• each -L2A- is independently saturated aliphatic C1-3alkylene;
• wherein:
• each —R2A4, —R2A5, —R2A6, —R2A7, and —R2A8 is optionally substituted, for example, with one or more substituents —R2B1 and/or one or more substituents —R2B2, and
• each —R2A1, —R2A2, R2A3, and -L2A- is optionally substituted, for example, with one or more substituents —R2B2,
• wherein:
• each —R2B1 is independently:
• —R2D1, —R2D2, —R2D3, —R2D4, —R2D5, —R2D6, —R2D7, —R2D8,
• -L2D-R2D4, -L2D-R2D5, -L2D-R2D6, -L2D-R2D7, or -L2D-R2D8;
• each —R2B2 is independently:
• —F, —Cl, —Br, —I,
• —CF3, —OCF3,
• —OH, -L2C-OH, —O-L2C-OH,
• —OR2C1, -L2C-OR2C1, —O-L2C-OR2C1,
• —SH, —SR2C1,
• —CN,
• —NO2,
• —NH2, —NHR2C1, —NR2C12, —NR2C2R2C3,
• -L2C-NH2, -L2C-NHR2C1, -L2C-NR2C12, -L2C-NR2C2R2C3,
• —O-L2C-NH2, —O-L2C-NHR2C1, —O-L2C-NR2C12, —O-L2C-NR2C2R2C3,
• —C(═O)OH, —C(═O)OR2C1,
• —C(═O)R2C1,
• —C(═O)NH2, —C(═O)NHR2C1, —C(═O)NR2C12, —C(═O)NR2C2R2C3,
• —NHC(═O)R2C1, —NR2C1C(═O)R2C1,
• —NHC(═O)OR2C1, —NR2C1C(═O)OR2C1,
• —OC(═O)NH2, —OC(═O)NHR2C1, —OC(═O)NR2C12, —OC(═O)NR2C2R2C3,
• —NHC(═O)NH2, —NHC(═O)NHR2C1,
• —NHC(═O)NR2C12, —NHC(═O)NR2C2R2C3,
• —NR2C1C(═O)NH2, —NR2C1C(═O)NHR2C1,
• —NR2C1C(═O)NR2C12, —NR2C1C(═O)NR2C2R2C3,
• —NHS(═O)2R2C1, —NR2C1S(═O)2R2C1,
• —S(═O)2NH2, —S(═O)2NHR2C1, —S(═O)2NR2C12, —S(═O)2NR2C2R2C3,
• —S(═O)R2C1, —S(═O)2R2C1, —OS(═O)2R2C1, or —S(═O)2OR2C1;
• wherein:
• each -L2C- is independently saturated aliphatic C1-5alkylene;
• in each group —NR2C2R2C3, R2C2 and R2C3, taken together with the nitrogen atom to which they are attached, form a 4-, 5-, 6-, or 7-membered non-aromatic ring having exactly 1 ring heteroatom or exactly 2 ring heteroatoms, wherein one of said exactly 2 ring heteroatoms is N, and the other of said exactly 2 ring heteroatoms is independently N or O;
• each —R2C1 is independently:
• —R2D1, —R2D2, —R2D3, —R2D4, —R2D5, —R2D6, —R2D7, —R2D8,
• -L2D-R2D4, -L2D-R2D5, -L2D-R2D6, -L2D-R2D7, or -L2D-R2D8;
• each —R2D1 is independently saturated aliphatic C1-6alkyl;
• each —R2D2 is independently aliphatic C2-6alkenyl;
• each —R2D3 is independently aliphatic C2-6alkynyl;
• each —R2D4 is independently saturated C3-6cycloalkyl;
• each —R2D5 is independently C3-6cycloalkenyl;
• each —R2D6 is independently non-aromatic C3-8heterocyclyl;
• each —R2D7 is independently C6-10carboaryl;
• each —R2D8 is independently C5-10heteroaryl;
• each -L2D- is independently saturated aliphatic C1-3alkylene;
• wherein:
• each —R2D4, —R2D5, —R2D6, —R2D7, and —R2D8 is optionally substituted, for example, with one or more substituents —R2E1 and/or one or more substituents —R2E2,
• each —R2D1, —R2D2, —R2D3, and -L2D- is optionally substituted, for example, with one or more substituents —R2E2, and
• wherein:
• each —R2E1 is independently saturated aliphatic C1-4alkyl, phenyl, or benzyl;
• each —R2E2 is independently:
• —F, —Cl, —Br, —I,
• CF3, —OCF3,
• —OH, -L2F-OH, —O-L2F-OH,
• —OR2F1, -L2F-OR2F1, —O-L2F-OR2F1,
• —SH, —SR2F1,
• —CN,
• —NO2,
• —NH2, —NHR2F1, —NR2F12, —NR2F2R2F3,
• -L2F-NH2, -L2F-NHR2F1, -L2F-NR2F12, -L2F-NR2F2R2F3,
• —C(═O)OH, —C(═O)OR2F1,
• —C(═O)NH2, —C(═O)NHR2F1, —C(═O)NR2F12, or —C(═O)NR2F2R2F3;
• wherein:
• each —R2F1 is independently saturated aliphatic C1-4alkyl, phenyl, or benzyl;
• each -L2F- is independently saturated aliphatic C1-5alkylene;
• and
• in each group —NR2F2R2F3, R2F2 and R2F3, taken together with the nitrogen atom to which they are attached, form a 4-, 5-, 6-, or 7-membered non-aromatic ring having exactly 1 ring heteroatom or exactly 2 ring heteroatoms, wherein one of said exactly 2 ring heteroatoms is N, and the other of said exactly 2 ring heteroatoms is independently N or O;
• with the proviso that the compound is not a compound selected from the following compounds:
• Cyclopropanecarboxylic acid (5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide (PP-001) (WW-001);
• Cyclopropanecarboxylic acid [5-(3-acetylamino-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide (PP-002) (WW-002);
• Cyclopropanecarboxylic acid {5-[4-(4-methyl-piperazin-1-yl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl}-amide (PP-003) (WW-003);
• Cyclopropanecarboxylic acid [5-(3-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amide (PP-004) (WW-004);
• Cyclopropanecarboxylic acid [5-(4-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amide (PP-005) (WW-005);
• Cyclopropanecarboxylic acid [5-(6-methoxy-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide (PP-006) (WW-006);
• Cyclopropanecarboxylic acid [5-(3-fluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amide (PP-007) (WW-007);
• Cyclopropanecarboxylic acid [5-(4-hydroxy-3,5-dimethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amide (PP-008) (WW-008);
• 4-[2-(Cyclopropanecarbonyl-amino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-N-(2-dimethylamino-ethyl)-benzamide (PP-009) (WW-009);
• Cyclopropanecarboxylic acid [5-(2,4-dimethoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide (PP-010) (WW-010);
• Cyclopropanecarboxylic acid [5-(3-methanesulfonylamino-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amide (PP-011) (WW-011);
• Cyclopropanecarboxylic acid [5-(2-dimethylamino-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amide (PP-012);
• Cyclopropanecarboxylic acid [5-(3-chloro-4-fluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amide (PP-013);
• Cyclopropanecarboxylic acid [5-(3-trifluoromethoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amide (PP-014);
• Cyclopropanecarboxylic acid [5-((E)-styryl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amide (PP-015);
• Cyclopropanecarboxylic acid (5-thiophen-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide (PP-016);
• 3-Cyclohexyl-N-[5-(4-hydroxy-3,5-dimethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-propionamide (PP-017);
• Cyclohexanecarboxylic acid (5-thiophen-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide (PP-018);
• Furan-2-carboxylic acid [5-(3-fluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide (PP-019);
• Furan-2-carboxylic acid [5-(4-hydroxy-3,5-dimethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amide (PP-020);
• 3-Methoxy-N-(5-thiophen-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-propionamide (PP-021);
• 4-[2-(Cyclopropanecarbonyl-amino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-N-(2-hydroxy-ethyl)-benzamide (PP-022);
• Cyclopropanecarboxylic acid (5-furan-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide (PP-023);
• N-[5-(3-Amino-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridin-3-yl-propionamide (PP-024);
• N-[6-(5-Methanesulfonyl-pyridin-3-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acetamide (PP-025);
• and
• N-[6-(3,4-Dimethoxy-phenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acetamide (PP-026).