Back to results
US 2014/0155585 A1Published application
Haptens of risperidone and paliperidone
AssigneesOrtho-Clinical Diagnostics, Inc., Janssen Pharmaceutica NV
InventorsPieter Rik HASPESLAGH, Maarten VLIEGEN, Eric HRYHORENKO, Thomas R. DeCORY, Banumathi SANKARAN
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds of Formula I, wherein R1 and R2 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from risperidone and paliperidone. The invention also relates to conjugates of a risperidone or paliperidone hapten and a protein.
Claims29
The compound of Formula I
- wherein:
- R1 is H, or OH;
- R2 is O(CH2)rNH2,
- O(CH2)rNHC(O)(CH2)mCO2H, or Z—(Y)p-G;
- wherein:
- Z is selected from the group consisting of:
- —N(R4)—, —O—, —S—, -heteroalkyl-;
- R4 is H, an alkyl group, cycloalkyl group, aralkyl group or substituted or unsubstituted aryl group;
- Y is an organic spacer group;
- G is a functional linking group capable of binding to a carrier;
- p is 0, or 1;
- r is 1, 2, 3, 4, or 5;
- m is 1, 2, 3, 4, or 5;
- n is 1, 2, 3, 4, or 5.
11 more elements
Dependencies are inferred from the claim text.