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US 2014/0155583 A1Published application
Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen
AssigneeUniversitatsklinikum Freiburg
InventorsUrsula Elsässer-Beile, Philipp Wolf, Dorothee Gierschner, Patrick Bühler, Ulrich Wetterauer
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Abstract
Isolated monoclonal antibodies or an antigen binding portion thereof which bind to prostate specific membrane antigen in its native form occurring on the surface of tumor cells characterized in that it is linked to a label or a cytotoxic agent or constructed as a part of a bispecific antibody or a recombinant diabody.
Claims10
An isolated monoclonal antibody or an antigen-binding portion thereof which
- a) binds to a prostate specific membrane antigen in its native form,
- b) binds strongly to LNCAP cells but not or only minimally to cells which lack expression of prostate specific membrane antigen, and
- c) comprises at least three sequences selected from the group consisting of SEQ ID NO:25, 31, 27, 32, 33 and 30, or at least three sequences from the group consisting of SEQ ID NO:25, 26, 27, 28, 29 and 30.
Dependencies are inferred from the claim text.