Back to results
US 2014/0155577 A1Published application
Self-assembly of therapeutic agent-peptide nanostructures
AssigneeOhio State Innovation Foundation
InventorsJonathan R. Parquette, Se Hye Kim, Mark W. Grinstaff, Jonah A. Kaplan
Life of this patent
Estimating the term…
Abstract
Disclosed are conjugates of hydrophobic drugs linked to protected or unprotected amino acids or peptides. The disclosed conjugates are amphiphilic and can self assemble into nanotubes. Nanotubes comprising the conjugates are also described and can have high loading of the drug and protect it from degradation or elimination. The nanotubes are well suited to deliver hydrophobic and unstable drugs to individuals.
Claims21
A conjugate for forming a self assembled nanotube;
- comprising:
- a hydrophobic drug, a hydrophilic amino acid residue or peptide;
- and a linker moiety joining the hydrophobic drug to the hydrophilic amino acid or peptide, wherein the conjugate forms a self assembled nanotube.
Dependencies are inferred from the claim text.