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US 2014/0155497 A1Published application
Heparosan-based biomaterials and coatings and methods of production and use thereof
AssigneeThe Board of Regents of the University of Oklahoma
InventorPaul L. DeAngelis
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Abstract
Biomaterial compositions that include an isolated heparosan polymer are disclosed, as well as kits containing such biomaterial compositions and methods of producing and using such biomaterial compositions.
Claims21
A biomaterial composition, the composition comprising:
- an isolated heparosan polymer, wherein the isolated heparosan polymer is biocompatible with a mammalian patient and is represented by the structure (-GlcUA-β1,4-GlcNAc-α1,4-)n, and wherein at least one of:
- n is about 1,000;
- and
- the molecular weight of the isolated heparosan polymer is in a range of from about 0.5 MDa to about 4.5 MDa.
1 more element
A biomaterial composition, the composition comprising:
- an isolated derivatized heparosan polymer, wherein the isolated derivatized heparosan polymer is biocompatible with a mammalian patient and is represented by the structure (-GlcUA-β1,4-GlcNAc-α1,4-)n, wherein n is a positive integer greater than or equal to 1, and wherein the derivatized heparosan polymer is not found in nature.
A biomaterial composition, the composition comprising:
- an isolated heparosan polymer, wherein the isolated heparosan polymer is biocompatible with a mammalian patient, and wherein the isolated heparosan polymer is represented by the structure (-GlcUA-β1,4-GlcNAc-α1,4-)n, wherein n is a positive integer greater than or equal to 1;
- a substrate;
- and
- wherein the isolated heparosan polymer is attached to the substrate.
1 more element
21-28. (canceled)
Dependencies are inferred from the claim text.