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US 2014/0155490 A1Published application
Therapeutic compounds
AssigneeUniversity of Florida Research Foundation, Inc.
InventorRaymond G. Booth
Life of this patent
Estimating the term…
Abstract
The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C disorders, including diseases and disorders mediated by GPCRs.
Claims21
1-9. (canceled)
A method of treating obesity in a subject comprising administering to the subject identified as in need thereof a PAT compound capable of selectively inhibiting the 5-HT2c relative to 5-HT2a or 5-HT2b.
13-14. (canceled)
A compound that is
- wherein,
- R1 is independently H, NH2, NH(alkyl), N(alkyl)2;
- R2 is independently —(CH2)n-;
- Each n is independently 1 or 2;
- R3 is independently H, OH, or halo;
- R4 is independently H, OH, or halo
- Each R5 is independently H, alkyl, or halo;
- R6 is independently H or alkyl;
- and
- R7 independently H, N(alkyl)2;
- or salt, hydrate or solvate thereof.
8 more elements
A compound of the formula:
- wherein,
- R1 is independently H, NH2, NH(alkyl), N(alkyl)2;
- R2 is independently —(CH2)n-;
- Each n is independently 1 or 2;
- R3 is independently H, OH, or halo;
- R4 is independently H, OH, or halo
- Each R5 is independently H, alkyl, or halo;
- R6 is independently H or alkyl;
- R7 independently H, N(alkyl)2;
- and
- R8 is independently aryl or heteroaryl, each optionally substituted with 1-4 independent R5;
- or salt, hydrate or solvate thereof.
9 more elements
Dependencies are inferred from the claim text.