Administration of Iloprost as Aerosol Bolus
OwnerTobias Gessler, Thomas Schmehl +2inventors
InventorsTobias Gessler, Thomas Schmehl, Werner Seeger, Robert Voswinckel
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Abstract
The present invention relates to novel methods, compositions and kits useful for the treatment of pulmonary diseases such as pulmonary arterial hypertension. In particular, aerosolisable compositions of iloprost are provided which are for use in inhalation therapy. Their administration is by bolus inhalation, which is patient-friendly, effective, and well tolerated. Bolus inhalation may, for example, be achieved using an efficient nebuliser based on the vibrating mesh technology.
Claims29
1-15. (canceled)
A pharmaceutical composition comprising an active ingredient selected from iloprost and salts thereof for use as an aerosol for pulmonary administration to a patient in need thereof, wherein an amount of the composition comprises an effective single dose of the active ingredient and is provided in aerosolised form for bolus inhalation within a period of 2 minutes or less.
A method of treating a patient suffering from pulmonary arterial hypertension, comprising:
- (a) providing a pharmaceutical composition comprising an active ingredient selected from iloprost and salts thereof;
- (b) providing an inhaler adapted for delivering an amount of the composition comprising an effective single dose of the active ingredient in aerosolised form for bolus inhalation within a period of 2 minutes or less;
- and
- (c) administering the composition as an aerosol bolus to the patient by using the inhaler.
A pharmaceutical kit comprising:
- (a) a composition comprising an active ingredient selected from iloprost and salts thereof;
- and
- (b) an inhaler adapted for providing an amount of the composition comprising an effective single dose of the active ingredient in aerosolised form for bolus inhalation within a period of 2 minutes or less.
A nebulised aerosol comprising at least about 0.5 μg of iloprost or an equivalent amount of a salt thereof per litre of aerosol volume.
Dependencies are inferred from the claim text.