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AssigneeThe University of Hong Kong
InventorsChaminda Jayampath SENEVIRATNE, Yi Tsun Richard KAO, Lakshman Perera SAMARANAYAKE, Kwok Yung YUEN, Dan YANG, Yu WANG, Sze Wah Sarah WONG
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Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections.
A method for reducing growth of a fungus comprising contacting a fungal cell with a compound having a structure:
A method of treating and preventing against fungal infections in a subject which comprises administering to the subject an effective amount of a compound having the structure:
A medical device having a surface wherein at least a portion of the surface comprises a coating wherein the coating comprises a compound having a structure:
Dependencies are inferred from the claim text.