Micro-rna's that regulate muscle cells
AssigneeBoard of Regents, The University of Texas System
InventorDeepak SRIVASTAVA
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Abstract
The present invention describes microRNAs that regulate the differentiation, proliferation and death of cardiac and skeletal muscles cells. These molecules represent unique targets in the developmental pathways of muscle cells. They also can be used as active agents to induce differentiation in progenitor cells, and their down-regulation permits the maintenance and expansion of progenitor cell populations.
Claims23
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A method of modulating the proliferation, differentiation or death of a muscle cell in vivo comprising contacting said cell with an antagonist of miR-1-1 or miR-1-2 function or expression.
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A method of inhibiting differentiation of a muscle cell progenitor in vivo comprising inhibiting the function or expression of one or more of miR-1-1 or miR-1-2.
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Dependencies are inferred from the claim text.