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US 2014/0155459 A1Published application
Compositions and Methods of Using Micro RNAs
AssigneeYale University
InventorsHyung J. Chun, Jongmin Kim
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AssigneeYale University
InventorsHyung J. Chun, Jongmin Kim
Estimating the term…
The present invention provides compositions and methods of using microRNAs to treat pulmonary arterial hypertension. In one aspect, methods are disclosed that are useful for identifying a subject in need of therapeutic intervention to reduce or improve a symptom of pulmonary arterial hypertension, reducing proliferation of pulmonary vascular cells in a subject, or treating pulmonary arterial hypertension in a subject. In another aspect, compositions include an inhibitor of fibroblast growth factor 2 (FGF2) expression comprising at least one of: a mature sequence of miR-424 or miR-503; a pri-miRNA of miR-424 or miR-503; a pre-miRNA of miR-424 or miR-503; and the complement thereof. Pharmaceutical compositions for reducing proliferation of pulmonary vascular cells in a subject in need thereof and biomarker panels are also disclosed.
A composition comprising an inhibitor of fibroblast growth factor 2 (FGF2) expression comprising at least one of:
A method of identifying a subject in need of therapeutic intervention to reduce or improve a symptom of pulmonary arterial hypertension comprising, detecting an alteration in the level of a biomarker selected from the group consisting of fibroblast growth factor 2 (FGF2), apelin (APLN), miR-424, and miR-503 in a sample from the subject relative to a reference, thereby identifying the subject as in need of therapeutic intervention to reduce or improve the symptom of pulmonary arterial hypertension.
A method of reducing proliferation of pulmonary vascular cells in a subject in need thereof comprising administering to the pulmonary vascular cells of the subject a composition comprising an inhibitor of fibroblast growth factor 2 (FGF2) expression comprising at least one of:
A method of treating pulmonary arterial hypertension in a subject in need thereof comprising administering to the pulmonary vascular cells of the subject an inhibitor of fibroblast growth factor 2 (FGF2) expression comprising at least one of:
A biomarker panel comprising fibroblast growth factor 2 (FGF2), apelin (APLN), miR-424 and miR-503 or capture molecules that specifically bind the biomarkers.
Dependencies are inferred from the claim text.