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US 2014/0155447 A1Published application
Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents
AssigneeN30 Pharmaceuticals, Inc.
InventorsJan Wasley, Gary J. Rosenthal, Xicheng Sun, Sarah Strong, Jian Qiu
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Abstract
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
Claims19
A method of treatment of pulmonary disorders comprising administering a therapeutically effective amount of a compound of formula I or pharmaceutically acceptable salts thereof:
- wherein:
- Ar is selected from the group consisting of phenyl and thiophen-yl;
- R1 is selected from the group consisting of unsubstituted imidazolyl, substituted imidazolyl, chloro, bromo, fluoro, hydroxy, and methoxy;
- R2 is selected from the group consisting of hydrogen, methyl, chloro, fluoro, hydroxy, methoxy, ethoxy, propoxy, carbamoyl, dimethylamino, amino, formamido, and trifluoromethyl;
- and
- X is selected from the group consisting of CO and SO2.
3 more elements
A method of treatment of pulmonary disorders comprising administering a therapeutically effective amount of a compound of formula II or pharmaceutically acceptable salts thereof:
- wherein:
- Ar is selected from the group consisting of phenyl and thiophen-yl;
- R4 is selected from the group consisting of unsubstituted imidazolyl and substituted imidazolyl;
- R5 is selected from the group consisting of hydrogen, fluoro, hydroxy, and methoxy;
- R6 is selected from the group consisting of hydrogen, chloro, bromo, and fluoro;
- R7 is selected from the group consisting of hydrogen, and methyl;
- and
- R8 is selected from the group consisting of CONH2, SO2NH2, and NHSO2CH3.
5 more elements
Dependencies are inferred from the claim text.