Tetrahydronaphthalene derivatives
AssigneeConcert Pharmaceuticals, Inc.
InventorsRoger Tung, Craig E. Masse, Bhaumik A. Pandya
Life of this patent
Estimating the term…
Abstract
This invention relates to novel tetrahydronaphthalene derivatives, and pharmaceutically acceptable salts thereof according to the following formulae, in one embodiment: as described herein. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a selective T-type calcium channel blocker.
Claims38
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- Ra, Rb and Rc are each independently selected from —CH3 and —CD3;
- Y1a and Y1b are each deuterium;
- Y2a and Y2b are the same and are selected from hydrogen and deuterium;
- Y3a and Y3b are each deuterium;
- Y4a and Y4b are each deuterium;
- and
- R1 is selected from —CH3 and —CD3;
- wherein any atom not designated as deuterium is present at its natural isotopic abundance.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A compound of Formula A:
- or a pharmaceutically acceptable salt thereof, wherein:
- Ra, Rb and Rc are each independently selected from —CH3 and —CD3;
- Y1a and Y1b are each deuterium;
- Y2a and Y2b are each independently selected from hydrogen and deuterium;
- Y3a and Y3b are each deuterium;
- Y4a and Y4b are each deuterium;
- Y5a and Y5b are each independently selected from hydrogen and deuterium;
- Y6a and Y6b are each independently selected from hydrogen and deuterium;
- Y7a and Y7b are each independently selected from hydrogen and deuterium;
- Y8 is hydrogen;
- Y9 is hydrogen;
- and
- R1 is selected from —CH3 and —CD3;
- and wherein any atom not designated as deuterium is present at its natural isotopic abundance.
A compound of Formula C:
- or a pharmaceutically acceptable salt thereof, wherein
- Rd and Re are each hydrogen;
- Rf is ORc wherein Rc is —CH3;
- Y3a and Y3b are each deuterium;
- Y5a and Y5b are each independently selected from hydrogen and deuterium;
- Y8 is hydrogen;
- Y9 is hydrogen;
- R1 is selected from —CH3 and —CD3;
- and
- each of Y2a, Y2b, Y6a, Y6b, Y7a and Y7b is the same and is either hydrogen or deuterium, and wherein any atom not designated as deuterium is present at its natural isotopic abundance.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.