Cosmetic Use of Substituted Amino Heterocylic Carbamoyl Analogs and Related Compounds

A method for improving the aesthetic appearance of human skin comprising topically applying to an area of the skin in need thereof, a composition comprising a cosmetically acceptable vehicle and an effective amount of a collagen-stimulating compound of formula I:

• where:
• X is selected from O, S, or NRN;
• and
• R1 and R3 are independently a group of the form —[C(Ra)2]m-G-[C(Ra)2]n—Ra, where G is selected from a bond (i.e. absent), O, S, or NRN, and “m” and “n” are independently selected, at each occurrence, from an integer from 0 (zero) to 6;
• R2 and R4 are independently selected from the group consisting of Ra, C1-6 alkyl, alkenyl, alkynyl, and aryl, each of which may be optionally substituted with one or more groups Ra;
• L is selected from a CO, CO2, SO, SO2, PO3, or a bond (i.e. absent);
• wherein Ra is independently, at each occurrence, selected from hydrogen, halogen (F, Cl, Br, or I);
• —OH;
• —NH2;
• —NRNRN;
• —SH;
• —CN;
• oxo;
• —CHO;
• —CO2H;
• —O—(C═O)—H;
• —O—(C═O)—C1-10 alkyl;
• —O—(C═O)—Ar;
• —(C═O)—O—C1-10 alkyl;
• —(C═O)—O—Ar;
• —(C═O)—NRNRN;
• —O—C1-10 alkyl;
• —O—Ar;
• —S—C1-10 alkyl;
• —S—Ar;
• —Ar;
• —C1-10 alkyl;
• —NRN—CHO;
• —NRN—(C═O)—C1-10 alkyl;
• —C1-10 alkyl-O—C1-10 alkyl;
• perfluoroalkyl;
• epoxy;
• azido;
• thiocyanate;
• —SO2—RN;
• or nitro;
• wherein RN is independently selected, at each occurrence, from hydrogen or a C1-16 hydrocarbon radical, optionally substituted with halogen (F, Cl, Br, or I);
• —OH;
• —NH2;
• —NR*R*;
• —SH;
• —CN;
• oxo;
• —CHO;
• —CO2H;
• —O—(C═O)—H;
• —O—(C═O)—C1-10 alkyl;
• —O—(C═O)—Ar;
• —(C═O)—O—C1-10 alkyl;
• —(C═O)—O—Ar;
• —(C═O)—NR*R*;
• —O—C1-10 alkyl;
• —O—Ar;
• S—C1-10 alkyl;
• —S—Ar;
• —Ar;
• —C1-10 alkyl;
• —NR*—CHO;
• —NR*—(C═O)—C1-10 alkyl;
• C1-10 alkyl-O—C1-10 alkyl;
• perfluoroalkyl;
• epoxy;
• azido;
• thiocyanate;
• —SO2—R*;
• or nitro;
• wherein R* is independently hydrogen or a C1-16 hydrocarbon radical;
• where any two adjacent groups RN may together form a 5 or 6 membered ring;
• or a cosmetically acceptable salt thereof;
• and wherein said compound comprises from about 0.00001% to about 0.5% by weight of the composition.

A cosmetic composition for improving the aesthetic appearance of human skin comprising a cosmetically acceptable vehicle, one or more skin active agents or cosmetic excipients, and an effective amount of a collagen-stimulating compound of formula I:

• where:
• X is selected from O, S, or NRN;
• and
• R1 and R3 are independently a group of the form —[C(Ra)2]m-G-[C(Ra)2]n—Ra, where G is selected from a bond (i.e. absent), O, S, or NRN, and “m” and “n” are independently selected, at each occurrence, from an integer from 0 (zero) to 6;
• R2 and R4 are independently selected from the group consisting of Ra, C1-6 alkyl, alkenyl, alkynyl, and aryl, each of which may be optionally substituted with one or more groups Ra;
• L is selected from a CO, CO2, SO, SO2, PO3, or a bond (i.e. absent);
• wherein Ra is independently, at each occurrence, selected from hydrogen, halogen (F, Cl, Br, or I);
• —OH;
• —NH2;
• —NRNRN;
• —SH;
• —CN;
• oxo;
• —CHO;
• —CO2H;
• —O—(C═O)—H;
• —O—(C═O)—C1-10 alkyl;
• —O—(C═O)—Ar;
• —(C═O)—O—C1-10 alkyl;
• —(C═O)—O—Ar;
• —(C═O)—NRNRN;
• —O—C1-10 alkyl;
• —O—Ar;
• —S—C1-10 alkyl;
• —S—Ar;
• —Ar;
• —C1-10 alkyl;
• —NRN—CHO;
• —NRN—(C═O)—C1-10 alkyl;
• —C1-10 alkyl-O—C1-10 alkyl;
• perfluoroalkyl;
• epoxy;
• azido;
• thiocyanate;
• —SO2—RN;
• or nitro;
• wherein RN is independently selected, at each occurrence, from hydrogen or a C1-16 hydrocarbon radical, optionally substituted with halogen (F, Cl, Br, or I);
• —OH;
• —NH2;
• —NR*R*;
• —SH;
• —CN;
• oxo;
• —CHO;
• —CO2H;
• —O—(C═O)—H;
• —O—(C═O)—C1-10 alkyl;
• —O—(C═O)—Ar;
• —(C═O)—O—C1-10 alkyl;
• —(C═O)—O—Ar;
• —(C═O)—NR*R*;
• —O—C1-10 alkyl;
• —O—Ar;
• —S—C1-10 alkyl;
• —S—Ar;
• —Ar;
• —C1-10 alkyl;
• —NR*—CHO;
• —NR*—(C═O)—C1-10 alkyl;
• —C1-10 alkyl-O—C1-10 alkyl;
• perfluoroalkyl;
• epoxy;
• azido;
• thiocyanate;
• —SO2—R*;
• or nitro;
• wherein R* is independently hydrogen or a C1-16 hydrocarbon radical;
• where any two adjacent groups RN may together form a 5 or 6 membered ring;
• or a cosmetically acceptable salt thereof;
• and wherein said compound comprises from about 0.00001% to about 0.5% by weight of the composition.