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US 2014/0155440 A1Published application
Cysteine and cystine bioisosteres to treat schizophrenia and reduce drug cravings
AssigneesMarquette University, UWM Research Foundation, Inc.
InventorsJames M. Cook, David A. Baker, Edward Merle Johnson, II, Wenyuan Yin, Ranjit Singh Verma
Life of this patent
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Abstract
The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.
Claims12
A compound having the formula:
- wherein R1 is H, a branched or straight chain C1 to C5 alkyl, or
- each R2 is independently H or
- wherein R4 is a branched or unbranched C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, aryloxy, benzyl, or phenyl;
- and
- each R3 is independently
- wherein each R5 is independently H, a branched or unbranched C1-C6 alkyl, C3-C6 cycloalkyl, phenyl, or benzyl;
- or a salt or hydrate of said compound.
4 more elements
Dependencies are inferred from the claim text.