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US 2014/0155434 A1Published application
Thermogelling anaesthetic compositions
AssigneePharmanest AB
InventorsMark Sundberg, Arne Brodin, Nils Kallberg
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Abstract
The present invention relates to a thermogelling pharmaceutical composition comprising local anaesthetics in base form and which is suitable for topical administration. The compositions further comprise a polyoxyethylene castor oil and one or more surfactants to obtain thermogelling characteristics.
Claims15
A method of treating pain during an obstetric or gynaecological procedure which method comprises:
- (i) application to a mucosal surface of a patient in need of such pain treatment of a composition comprising:
- 1 to 10% by weight of one or more local anaesthetics in base form selected from the group lidocaine, prilocaine and mepivacaine,
- said one or more local anaesthetics being solubilized in 10 to 30% by weight of a polyoxyethylene castor oil,
- 15 to 30% by weight of one or more non-ionic block copolymers of poly(oxyethylene) and poly(oxypropylene) type, and
- water,
- wherein the pH of the composition is at least the value of the pKa of said one or more local anaesthetics;
- wherein said application is carried out by intravaginal, intracervical, pericervical or intrauteral administration of said composition, and
- (ii) formation of a thermogel on said mucosal surface.
5 more elements
Dependencies are inferred from the claim text.