Activators and therapeutic applications thereof
AssigneeThe Johns Hopkins University
InventorsMarikki Laiho, Karita Peltonen
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Abstract
The invention presents methods of identifying small molecule compounds that are activators of tumor suppressor protein p53 pathway, and its associated family members p63 and p73, function. The invention is further drawn to methods of killing tumor cells and treating cancers or other conditions requiring activation of the p53 family member pathways and DNA damage response pathways with the small molecules.
Claims5
-9. (canceled)
A pharmaceutical composition comprising a compound having the following formula:
- or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable carrier.
A method of treating cancer, comprising administering to a patient in need thereof a therapeutically effective amount of a compound having the formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.