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US 2014/0155423 A1Published application
Berbamine derivatives
AssigneeCity of Hope
InventorsDavid HORNE, Jun XIE, Angela L. PERKINS HARKI, Richard JOVE, Sangkil NAM, Wendong HUANG, Rongzhen XU
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Abstract
The invention provides novel berbamine derivatives, and compositions or pharmaceutical compositions thereof. These berbamine derivatives have shown higher potency in killing cancer/tumor cells comparing to berbamine, and can be used in cancer/tumor treatments.
Claims5
A compound comprising the following structure of Structure A
- including pharmaceutically acceptable variants thereof, wherein:
- R is selected from the group consisting of —C(═O)—(CH2)nNR′R″ and —(CH2)nNR′R″;
- R′ is selected from the group consisting of H, substituted and unsubstituted alkyl, and substituted and unsubstituted acyl groups;
- R″ is selected from the group consisting of H, substituted and unsubstituted alkyl, and substituted and unsubstituted acyl groups;
- and
- n is 2, 3, 4, . . . , 30.
3 more elements
Dependencies are inferred from the claim text.