Compounds and methods

A compound according to Formula (I):

• wherein:
• m is 0, 1, or 2;
• n is 0, 1, 2, or 3;
• X1, X2, X3, X4, and X5 are each independently selected from N, N+—O−, CH, and CR5, wherein 0-3 of X1, X2, X3, X4, and X5 are N or N+—O− and 1-3 of X1, X2, X3, X4, and X5 are CR5;
• one of Y1 and Y2 is O or NR8 and the other is a bond;
• or X1 is CR5, Y1 is NR8, Y2 is a bond, and R5 and R8 taken together with the atoms to which they are attached form a five to seven membered ring, optionally containing an additional heteroatom selected from oxygen, nitrogen, and sulfur, which ring is optionally substituted by (C1-C4)alkyl;
• Cy is (C3-C8)cycloalkyl, heterocycloalkyl, phenyl, or 5- or 6-membered heteroaryl, each of which is optionally substituted one, two, or three times, independently, by (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, halogen, oxo, cyano, hydroxyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy, —((C0-C3)alkyl)NHCO2R7, —((C0-C3)alkyl)N((C1-C4)alkyl)C2R7, —((C0-C3)alkyl)NHC(O)R7, —((C0-C3)alkyl)N((C1-C4)alkyl)C(O)R7, —((C0-C3)alkyl)CO2R7, —((C0-C3)alkyl)CONR7R8, —((C0-C3)alkyl)C(O)R7, (C1-C4)alkoxy(C1-C6)alkyl, amino(C1-C6)alkyl, ((C1-C4)alkyl)((C1-C4)alkyl)amino(C1-C6)alkyl, (C1-C4)alkylamino(C1-C6)alkyl, amino, (C1-C4)alkylamino, ((C1-C4)alkyl(C1-C4)alkyl)amino, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, or heterocycloalkyl;
• Z is O, S, SO2, C═O, NR6, or a bond;
• A1, A2, A3, A4, and A5 are each independently selected from N, N+—O−, CH, and CR10, wherein 0-3 of A1, A2, A3, A4, and A5 are N or N+—O− and 0-3 of A1, A2, A3, A4, and A5 are CR10;
• R1 is (C3-C6)alkyl, (C3-C6)haloalkyl, (C3-C8)cycloalkyl, (C3-C6)alkoxy, (C1-C6)alkoxy(C1-C2)alkyl, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, or heterocycloalkyl, each of which is optionally substituted one, two, or three times, independently, by R5;
• R2 is hydrogen, (C1-C6)alkyl, or (C1-C6)haloalkyl;
• or R1 and R2 taken together with the carbon atom to which they are attached form a three to eight membered ring, optionally containing a heteroatom selected from oxygen, nitrogen, and sulfur, which ring is optionally substituted one, two, or three times, independently, by R5;
• R3 and R3a are each independently hydrogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, halogen, (C1-C6)alkoxy, amino, (C1-C4)alkylamino, or ((C1-C4)alkyl)((C1-C4)alkyl)amino;
• each R4 is independently selected from hydrogen, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, —CO2R7, —CONR7R8, —OR9, and —NR8R9, wherein said (C1-C6)alkyl or (C1-C6)haloalkyl is optionally substituted by hydroxyl, —OR9, —CO2R7, —CONR7R8, or —NR8R9;
• each R4a is independently selected from hydrogen, halogen, hydroxyl, amino, and (C1-C6)alkyl;
• or R4 and R4a taken together with the carbon atom to which they are attached form a three to eight membered ring, optionally containing a heteroatom selected from oxygen, nitrogen, and sulfur, which ring is optionally substituted by cyano, (C1-C4)alkyl, (C1-C4)haloalkyl, (C3-C6)cycloalkyl, —CO2R7, —CONR7R8, hydroxyl, hydroxy(C1-C6)alkyl, (C1-C4)alkoxy, (C1-C4)alkoxy(C1-C6)alkyl, amino, (C1-C4)alkylamino, ((C1-C4)alkyl)((C1-C4)alkyl)amino, —NHCO2R7, —N((C1-C4)alkyl)CO2R7, —NHC(O)R7, or —N((C1-C4)alkyl)C(O)R7;
• each R5 is independently selected from (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, halogen, cyano, hydroxyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy, (C1-C4)alkoxy(C1-C6)alkyl, amino, (C1-C4)alkylamino, ((C1-C4)alkyl)((C1-C4)alkyl)amino, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, and heterocycloalkyl;
• R6 is hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, hydroxy(C1-C6)alkyl, (C1-C4)alkoxy(C1-C6)alkyl, —((C0-C3)alkyl)CO2R7, —((C0-C3)alkyl)CONR7R8, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, or heterocycloalkyl;
• R7 is hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, (C1-C4)alkoxy(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, or heterocycloalkyl;
• R8 is hydrogen, (C1-C6)alkyl, or (C1-C6)haloalkyl;
• or R7 and R8 taken together with the nitrogen atom to which they are attached form a four to eight membered ring, optionally containing an additional heteroatom selected from oxygen, nitrogen, and sulfur, which ring is optionally substituted by (C1-C4)alkyl, (C1-C4)haloalkyl, (C3-C6)cycloalkyl, —CO2H, —CO2(C1-C4)alkyl, hydroxyl, hydroxy(C1-C6)alkyl, (C1-C4)alkoxy, (C1-C4)alkoxy(C1-C6)alkyl, amino, (C1-C4)alkylamino, or ((C1-C4)alkyl)((C1-C4)alkyl)amino;
• R9 is —C(O)R7, —CO2R7, —C(O)NR7R8, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, or heterocycloalkyl, wherein said (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, or heterocycloalkyl is optionally substituted by —CO2R7, —CONH2, —CONH(C1-C4)alkyl, —CON((C1-C4)alkyl)((C1-C4)alkyl), hydroxyl, (C1-C4)alkoxy, amino, (C1-C4)alkylamino, ((C1-C4)alkyl)((C1-C4)alkyl)amino, —NHCO2R7, —N((C1-C4)alkyl)CO2R7, —NHC(O)R7, or —N((C1-C4)alkyl)C(O)R7;
• or R8 and R9 taken together with the nitrogen atom to which they are attached form a four to eight membered ring, optionally containing an additional heteroatom selected from oxygen, nitrogen, and sulfur, which ring is optionally substituted by cyano, (C1-C4)alkyl, (C1-C4)haloalkyl, (C3-C6)cycloalkyl, —CO2H, —CO2(C1-C4)alkyl, —CONR7R8, hydroxyl, hydroxy(C1-C6)alkyl, (C1-C4)alkoxy, (C1-C4)alkoxy(C1-C6)alkyl, amino, (C1-C4)alkylamino, ((C1-C4)alkyl)((C1-C4)alkyl)amino, —NHCO2R7, —N((C1-C4)alkyl)CO2R7, —NHC(O)R7, or —N((C1-C4)alkyl)C(O)R7;
• and
• R10 is (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, halogen, cyano, hydroxyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy, (C1-C4)alkoxy(C1-C6)alkyl, —((C0-C3)alkyl)CO2R7, —((C0-C3)alkyl)CONR7R8, amino(C1-C6)alkyl, ((C1-C4)alkyl)((C1-C4)alkyl)amino(C1-C6)alkyl, (C1-C4)alkylamino(C1-C6)alkyl, amino, (C1-C4)alkylamino, ((C1-C4)alkyl)((C1-C4)alkyl)amino, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, or heterocycloalkyl;
• or a salt thereof.