US 2014/0155412 A1 · OLIGOMER-DIARYLPIPERAZINE CONJUGATES

Abstract

The invention relates to (among other things) oligomer-diarylpiperazine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated diarylpiperazine compounds.

Claims11

Dependent claims

A method of treatment comprising administering a therapeutically effective amount of a compound to a subject in need of opioid receptor agonism, wherein the compound has a structure selected from the group consisting of

wherein, in each structure, R3 is either H or CH3, R5 is either H or CH3, X is a spacer moiety, and POLY is a water-soluble, non-peptidic oligomer.

Dependencies are inferred from the claim text.

Facts

Application

14/175,410Filed 7 Feb 2014

Priority

25 Jan 2008

Published

5 Jun 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

A61K 31/495
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having six-membered rings with two or more nitrogen atoms as the only ring…
A61K 47/60
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes: the organic…
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/12
Drugs for disorders of the alimentary tract or the digestive system: antidiarrhoeals

Family

Application61/062,330Us provisional application · filed 25 Jan 2008

Application12/864,481Continuation · filed 16 Sep 2011

Application14/175,410Continuation

US 2012/0004242 A1Published application

US 8,685,979 B2Related patent

US 9,061,026 B2Related patent

US 2014/0155412 A1This patent

From the US filing history. Foreign family members aren’t listed.

Abstract

Claims11

Dependent claims

wherein, in each structure, R3 is either H or CH3, R5 is either H or CH3, X is a spacer moiety, and POLY is a water-soluble, non-peptidic oligomer.

Dependencies are inferred from the claim text.

Facts

Application

14/175,410Filed 7 Feb 2014

Priority

25 Jan 2008

Published

5 Jun 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

A61K 31/495
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having six-membered rings with two or more nitrogen atoms as the only ring…
A61K 47/60
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes: the organic…
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/12
Drugs for disorders of the alimentary tract or the digestive system: antidiarrhoeals

Family

Application61/062,330Us provisional application · filed 25 Jan 2008

Application12/864,481Continuation · filed 16 Sep 2011

Application14/175,410Continuation

US 2012/0004242 A1Published application

US 8,685,979 B2Related patent

US 9,061,026 B2Related patent

US 2014/0155412 A1This patent

From the US filing history. Foreign family members aren’t listed.

Oligomer-diarylpiperazine conjugates

Life of this patent

Abstract

Claims11

Oligomer-diarylpiperazine conjugates

Life of this patent

Abstract

Claims11