Tuberculosis Biomarkers and Uses Thereof

A computer-implemented method for classifying an individual as either having a first evaluation of NED, or as having a second evaluation of EVD, said method comprising:

• a) retrieving on a computer biomarker information for an individual, wherein the biomarker information comprises a biomarker value that corresponds to at least one biomarker of Tables 1, 2, 4, 5 or 8 to 12;
• b) comparing said biomarker value of step a) to a biomarker value of a control population to determine if there is differential expression;
• and
• c) classifying the individual as having a first evaluation of NED when there is no differential expression in step b) of the biomarker value relative to said control population, and as having a second evaluation of EVD when there is differential expression of the biomarker value relative to the control population.

A computer program product comprising a computer readable medium embodying program code executable by a processor of a computing device or system, the program code comprising:

• a) code that retrieves data attributed to a biological sample from an individual, wherein the data comprises a biomarker value that corresponds to the at least one biomarker of Tables 1, 2, 4, 5 or 8 to 12;
• b) code for comparing the biomarker value of step a) to a biomarker value of a control population;
• and
• c) code that executes a classification method that indicates a first evaluation of NED when there is no differential expression of the individual's biomarker value in step b) relative to the control population, or second evaluation of EVD when there is differential expression of the individual's biomarker value relative to the control population.

A method for treating tuberculosis infection in an individual, comprising:

• diagnosing tuberculosis infection by causing to be determined a biomarker value corresponding N biomarker(s) of Tables 1, 2, 4, 5, or 8 to 12 in a biological sample of the individual,
• wherein said determination comprises comparing the biomarker value of the individual to the biomarker value in a control population for differential expression of the biomarker,
• wherein differential expression of the biomarker indicates the presence of tuberculosis infection in the individual,
• wherein N is at least one;
• and
• administering treatment for tuberculosis infection to the individual thereby diagnosed with tuberculosis infection.

An assay for diagnosing tuberculosis infection in an individual, comprising:

• causing to be determined a biomarker value corresponding to N biomarker(s) of Tables 1, 2, 4, 5, or 8 to 12 in a biological sample of the individual,
• wherein said determining comprises comparing the biomarker value of the individual to the biomarker value in a control population for differential expression of the biomarker,
• wherein differential expression of the biomarker indicates the presence of tuberculosis infection in the individual,
• wherein N is at least one and
• diagnosing an individual to have tuberculosis infection based on said differential expression of the biomarker.

A method for determining whether treatment for tuberculosis infection should be administered to a patient, comprising:

• a) causing an assay to be conducted for determining a biomarker value corresponding N biomarker(s) of Tables 1, 2, 4, 5, or 8 to 12 in a biological sample of the individual,
• wherein said determining comprises comparing the biomarker value of the individual to the biomarker value in a control population for differential expression of the biomarker,
• wherein differential expression of the biomarker indicates the presence of tuberculosis infection in the individual,
• wherein N is at least one
• b) diagnosing an individual to have tuberculosis infection based on said differential expression of the biomarker;
• and
• c) administering treatment for tuberculosis infection.

A method for determining whether treatment for tuberculosis infection should be administered to a patient, comprising:

• a) obtaining a biological sample from said patient
• b) causing an assay to be conducted for determining a biomarker value corresponding to N biomarker(s) of Tables 1, 2, 4, 5, or 8 to 12 in said biological sample of the individual,
• wherein said determining comprises comparing the biomarker value of the individual to the biomarker value in a control population for differential expression of the biomarker,
• wherein differential expression of the biomarker indicates the presence of tuberculosis infection in the individual,
• wherein N is at least one;
• c) diagnosing an individual to have tuberculosis infection based on said differential expression of the biomarker;
• and
• d) administering treatment for tuberculosis infection.

A method for treating recurrence or reactivation of tuberculosis infection in an individual, comprising:

• diagnosing recurrence or reactivation of tuberculosis infection by causing to be determined a biomarker value corresponding to N biomarker(s) of Tables 1, 2, 4, 5, or 8 to 12 in a biological sample of the individual,
• wherein said determination comprises comparing the biomarker value of the individual to the biomarker value in a control population for differential expression of the biomarker,
• wherein differential expression of the biomarker indicates the recurrence or reactivation of tuberculosis infection in the individual, and
• administering treatment for recurrence or reactivation of tuberculosis infection to the individual thereby diagnosed with recurrent or reactivated tuberculosis infection.

A method for modifying treatment of tuberculosis infection in an individual, comprising

• evaluating the status of tuberculosis infection by causing to be determined a biomarker value corresponding to N biomarker(s) of Tables 8 to 12 in a biological sample of the individual,
• wherein said evaluation comprises comparing the biomarker value of the individual to the biomarker value in a control population for differential expression of the biomarker,
• wherein differential expression of the biomarker indicates the need to intensify treatment of tuberculosis infection in the individual, and
• modifying treatment for tuberculosis infection to the individual thereby evaluated as in need of modified treatment of tuberculosis infection.