Pyrazolylaminopyridines as inhibitors of fak

A compound of formula (I):

• or a salt thereof, wherein:
• R1 is halo, CF3, C1-C6-alkyl, isopropenyl, (C2-C6-alkylene) C3-C6-cycloalkyl, C1-C6-alkoxy, or cyano;
• in R2, when p is other than 0, each R2 is independently F, Cl, CF3, methyl, methoxy, CH2CF3, —(X)q—C1-C4-alkylene-R4, —(X—C1-C4-alkylene)q-NR5—C(O)—R6, —(X—C1-C4-alkylene)q-(NR5)q—SOx—R7, —(X—C1-C4-alkylene)q-Y—N(R8)2, a 5- to 6-membered heterocycloalkyl-(R9)q group, or a 5- to 6-membered heteroaryl-(R10)r group;
• each R3 is independently H, C3-C6-cycloalkyl, C1-C6-alkyl, C1-C6alkoxy, C1-C6-alkylene-R4, —N(R)2, O—C1-C6-alkylene-R4, or, the R3 groups, together with Z form a 5- to 6-membered cycloalkyl or cycloheteroalkyl where the hetero atom is N or O and ring is optionally substituted on a carbon or heteroatom by methyl, C1-C4-alkylene-R4, or C3-C6-cycloalkyl;
• R4 is H, -(Q)q-N(R8)2, OH, SH, C1-C6-alkoxy, C1-C6-thioalkyl, or a 5- to 6-membered heterocycloalkyl-(R9)q group;
• R5 is H or C1-C6-alkyl;
• R6 is H, C1-C6-alkyl, C1-C6-alkoxy, N(R8)2, or a 5- to 6-membered heteroaryl-(R10)r group;
• R7 is C1-C6-alkyl, phenyl-(R9)q, or 5- to 6-membered heteroaryl-(R10)r
• R8 is independently H, C1-C6-alkyl, —O—C1-C6-alkyl or, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group;
• R9 is H, C1-C6-alkyl, C1-C6-alkoxy, -(Q)q-N(R8)2, -Q-C1-C6-alkyl, —C1-C6alkylR4, or 5- to 6-membered heterocycloalkyl;
• R10 is H, C1-C6-alkyl, C1-C6-alkoxy, or -Q-C2-C6-alkyl;
• R11 is C1-C6-alkyl, CF3, —CH2CF3, -(Q)q-C1-C4-alkylene-R4, -Q-N(R8)2, phenyl-(R5)s, a 5- to 6-membered heterocycloalkyl-(R9)q group, or a 5- to 6-membered heteroaryl-(R10)r group;
• R12 is H, C1-C6-alkyl, F, Cl, CF3, OH, CN, nitro, COOH, —COO—C1-C6-alkyl, —C1-C6-alkylOH, —C1-C6-alkylN(R8)2, —Y—N(R8)2, C3-C6-cycloalkyl-R14, —(X)q—C1-C6-alkylene-R4, —(X—C1-C6-alkylene)q-NR5—C(O)—R6, —(X—C1-C6-alkylene)q-(NR5)q—SOx—R7, —(X—C1-C6-alkylene)q-Y—N(R8)2, heterocycloalkyl-(R9)q, heteroaryl-(R8)r, or phenyl-(R15)s;
• R13 is H, F, Cl, C1-C6-alkyl, or C3-C6-cycloalkyl;
• or R12 and R13, together with the carbon atoms to which they are attached, form a fused 5- or 6-membered carbocycloalkyl or heterocycloralkyl group;
• R14 is independently H, C1-C6-alkyl. —NR5—SO2—R7, —Y—N(R8)2, or —(X)q—C1-C6-alkylene-R4;
• each R15 is independently F, Cl, CF3, C1-C3-alkyl, or C1-C3-alkoxy;
• p is 0, 1, 2, or 3;
• q is 0 or 1;
• r is 0, 1, or 2;
• s is 0, 1, 2, or 3;
• x is 1 or 2;
• Q is —C(O)—, —S(O)—, or —SO2—;
• X is NR5, O, S, —S(O)—, or —SO2—;
• Y is a bond, SO2, or C(O);
• and
• Z is N or CR5.