Chemical Compounds - 759

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein
• Q is selected from N and C(R3);
• D is selected from N and CH;
• R1 is selected from H, —CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3- to 5-membered carbocyclyl, 5-membered heterocyclyl, —OR1a, —SR1a, —N(R1a)2, —N(R1a)C(O)R1b, —N(R1a)N(R1a)2, —NO2, —C(O)H, —C(O)R1b, —C(O)2R1a, —C(O)N(R1a)2, —OC(O)N(R1a)2, —N(R1a)C(O)2R1a, —N(R1a)C(O)N(R1a)2, —OC(O)R1b, —S(O)R1b, —S(O)2R1b, —S(O)2N(R1a)2, —N(R1a)S(O)2R1b, —C(R1a)═N(R1a), and —C(R1a)═N(OR1a), wherein said C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3- to 5-membered carbocyclyl, and 5-membered heterocyclyl are optionally substituted with one or more R10;
• R1a in each occurrence is independently selected from H and C1-6alkyl, 3- to 5-membered carbocyclyl, and 5-membered heterocyclyl, wherein said C1-6alkyl, 3- to 5-membered carbocyclyl, and 5-membered heterocyclyl in each occurrence are optionally and independently substituted with one or more R10;
• R1b in each occurrence is independently selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3- to 5-membered carbocyclyl, and 5-membered heterocyclyl, wherein said C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3- to 5-membered carbocyclyl, and 5-membered heterocyclyl in each occurrence are optionally and independently substituted with one or more R10;
• R2 is selected from H, halo, —CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, heterocyclyl, —OR2a, —SR2a, —N(R2a)2, —N(R2a)C(O)R2b, —N(R2a)N(R2a)2, —NO2, —C(O)H, —C(O)R2b, —C(O)2R2a, —C(O)N(R2a)2, —OC(O)N(R2a)2, —N(R2a)C(O)2R2a, —N(R2a)C(O)N(R2a)2, —OC(O)R2b, —S(O)R2b, —S(O)2R2b, —S(O)2N(R2a)2, —N(R2a)S(O)2R2b, —C(R2a)═N(R2a), and —C(R2a)═N(OR2a), wherein said C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl are optionally substituted with one or more R20;
• R2a in each occurrence is independently selected from H, C1-6alkyl, carbocyclyl, and heterocyclyl, wherein said C1-6alkyl, carbocyclyl, and heterocyclyl in each occurrence are optionally and independently substituted with one or more R20;
• R2b in each occurrence is independently selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl, wherein said C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl in each occurrence are optionally and independently substituted with one or more R20;
• R3 is selected from H, halo, —CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, heterocyclyl, OR3a, —SR3a, —N(R3a)2, —N(R3a)C(O)R3b, —N(R3a)N(R3a)2, —NO2, —C(O)H, —C(O)R3b, —C(O)2R3a, —C(O)N(R3a)2, —OC(O)N(R3a)2, —N(R3a)C(O)2R3a, —N(R3a)C(O)N(R3a)2, —OC(O)R3b, —S(O)R3b, —S(O)2R3b, —S(O)2N(R3a)2, —N(R3a)S(O)2R3b, —C(R3a)═N(R3a), and —C(R3a)═N(OR3a), wherein said C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl are optionally substituted with one or more R30;
• R3a in each occurrence is independently selected from H, C1-6alkyl, carbocyclyl, and heterocyclyl, wherein said C1-6alkyl, carbocyclyl, and heterocyclyl in each occurrence are optionally and independently substituted with one or more R30;
• R3b in each occurrence is independently selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl, wherein said C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl in each occurrence are optionally and independently substituted with one or more R30;
• R4 is selected from H, —CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, heterocyclyl, —N(R4a)C(O)R4b, —N(R4a)N(R4a)2, —NO2, —C(O)H, —C(O)R4b, —C(O)2R4a, —C(O)N(R4a)2, —OC(O)N(R4a)2, —N(R4a)C(O)2R4a, —N(R4a)C(O)N(R4a)2, —OC(O)R4b, —S(O)R4b, —S(O)2R4b, —S(O)2N(R4a)2, —N(R4a)S(O)2R4b, —C(R4a)═N(R4a), and —C(R4a)═N(OR4a), wherein said C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl are optionally substituted with one or more R40;
• R4a in each occurrence is independently selected from H, C1-6alkyl, carbocyclyl, and heterocyclyl, wherein said C1-6alkyl, carbocyclyl, and heterocyclyl in each occurrence are optionally and independently substituted with one or more R40;
• R4b in each occurrence is independently selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl, wherein said C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl in each occurrence are optionally and independently substituted with one or more R40;
• R5 is independently selected from halo, —CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, heterocyclyl, —OR5a, —SR5a, —N(R5a)2, —N(R5a)C(O)R5b, —N(R5a)N(R5a)2, —NO2, —C(O)H, —C(O)R5b, —C(O)2R5a, —C(O)N(R5a)2, —OC(O)N(R5a)2, —N(R5a)C(O)2R5a, —N(R6a)C(O)N(R5a)2, —OC(O)R5b, —S(O)R5b, —S(O)2R5b, —S(O)2N(R5a)2, —N(R5a)S(O)2R5b, —C(R5a)═N(R5a), and —C(R5a)═N(OR5a);
• R5a in each occurrence is independently selected from H, C1-6alkyl, carbocyclyl, and heterocyclyl;
• R5b in each occurrence is independently selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl;
• R10 in each occurrence is independently selected from halo, —CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, heterocyclyl, —OR10a, —SR10a, —N(R10a)2, —N(R10a)C(O)R10b, —N(R10a)N(R10a)2, —NO2, —C(O)H, —C(O)R10b, —C(O)2R10a, —C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)2R10a, —N(R10a)C(O)N(R10a)2, —OC(O)R10b, —S(O)R10b, —S(O)2R10b, —S(O)2N(R10a)2, —N(R10a)S(O)2R10b, —C(R10a)═N(R10a), and —C(R10a)═N(OR10a);
• R10a in each occurrence is independently selected from H, C1-6alkyl, carbocyclyl, and heterocyclyl;
• R10b in each occurrence is independently selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl;
• R20 in each occurrence is independently selected from halo, —CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, heterocyclyl, —OR20a, —SR20a, —N(R20a)2, —N(R20a)C(O)R20b, —N(R20a)N(R20a)2, —NO2, —C(O)H, —C(O)R20b, —C(O)2R20a, —C(O)N(R20a)2, —OC(O)N(R20a)2, —N(R20a)C(O)2R20a, —N(R20a)C(O)N(R20a)2, —OC(O)R20b, —S(O)R20b, —S(O)2R20b, —S(O)2N(R20a)2, —N(R20a)S(O)2R20b, —C(R20a)═N(R20a), and —C(R20a)═N(OR20a);
• R20a in each occurrence is independently selected from H, C1-6alkyl, carbocyclyl, and heterocyclyl;
• R20b in each occurrence is independently selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl;
• R30 in each occurrence is independently selected from halo, —CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, heterocyclyl, —OR30a, —SR30a, —N(R30a)2, —N(R30a)C(O)R30b, —N(R30a)N(R30a)2, —NO2, —C(O)H, —C(O)R30b, —C(O)2R30a, —C(O)N(R30a)2, —OC(O)N(R30a)2, —N(R30a)C(O)2R30a, —N(R30a)C(O)N(R30a)2, —OC(O)R30b, —S(O)R30b, —S(O)2R30b, —S(O)2N(R30a)2, —N(R30a)S(O)2R30b, —C(R30a)═N(R30a), and —C(R30a)═N(OR30a);
• R30a in each occurrence is independently selected from H, C1-6alkyl, carbocyclyl, and heterocyclyl;
• R30b in each occurrence is independently selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl;
• R40 in each occurrence is independently selected from halo, —CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, heterocyclyl, —OR40a, —SR40a, —N(R40a)2, —N(R40a)C(O)R40b, —N(R40a)N(R40a)2, —NO2, —C(O)H, —C(O)R40b, —C(O)2R40a, —C(O)N(R40a)2, —OC(O)N(R40a)2, —N(R40a)C(O)2R40a, —N(R40a)C(O)N(R40a)2, —OC(O)R40b, —S(O)R40b, —S(O)2R40b, —S(O)2N(R40a)2, —N(R40a)S(O)2R40b, —C(R40a)═N(R40a), and —C(R40a)═N(OR40a);
• R40a in each occurrence is independently selected from H, C1-6alkyl, carbocyclyl, and heterocyclyl;
• and
• R40b in each occurrence is independently selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl.