Novel compounds

A compound of Formula (I) or a pharmaceutically acceptable salt thereof

• wherein:
• R1 is selected from the group consisting of:
• H,
• C1-C6 alkyl optionally substituted with cycloalkyl or C1-C3 alkoxy substituted with trimethylsilyl,
• (CH2)kNRaRa, wherein Ra is optionally substituted with halo or NRaRa,
• (CH2)mRb, wherein Rb is optionally substituted with C1-C3 alkyl, C1-C3 alkoxy or C(O)ORa, and
• benzyl optionally substituted with C1-C3 alkoxy, halo or C1-C3 alkyl;
• R2 is selected from the group consisting of:
• H, halo, CN, (CH2)nNRaRa, C(O)NRaRa, C(O)ORa, NRaC(O)Ra, (CH2)sORa,
• C1-C6 alkyl optionally substituted with Rb,
• indoline optionally substituted with C1-C3 alkyl or halo,
• C2-C6 alkynyl optionally substituted with OH, C1-C3 alkoxy, NRaRa or Rb,
• (CH2)mRb, wherein Rb is optionally substituted with C1-C3 alkyl,
• C(O)Rb, wherein Rb is optionally substituted with C1-C3 alkyl,
• (CH2)nRc wherein Rc is optionally substituted with one or more substituents selected from the group consisting of C1-C3 alkoxy, C1-C3 alkyl, NRaRa and halo, and
• (CH2)nRd wherein Rd is optionally substituted with one or more substituents selected from the group consisting of C1-C3 alkoxy, C1-C3 alkyl, NRaRa and halo;
• R3 is selected from the group consisting of:
• H,
• indoline, wherein said indoline is optionally substituted with one or more substituents selected from the group consisting of 1) C1-C6 alkyl optionally substituted with C3-C5 cycloalkyl or halo, 2) cycloalkyl substituted with C1-C3 alkyl, 3) halo, 4) C1-C3 alkoxy, 5) (CH2)tOH, and 6) ═O,
• indole optionally substituted with one or more 1) C1-C3 alkyl optionally substituted with halo, 2) halo, or 3) C1-C3 alkoxy,
• indazole optionally substituted with C1-C3 alkyl or halo,
• (CH2)tRc wherein Rc is optionally substituted with one or more substituents selected from the group consisting of:
• 1) Rb optionally substituted with C1-C3 alkyl, C(O)ORa or =0,
• 2) C1-C3 alkoxy,
• 3) C1-C4 alkyl optionally substituted with one to three F,
• 4) (CH2)tNRaC(O)ORa,
• 5) (CH2)tNRaRa,
• 6) halo,
• 7) —S—CH3,
• 8) —S(O)CH3, and
• 9) Rd,
• (CH2)tRd wherein Rd is optionally substituted with one or more substituents selected from the group consisting of C1-C4 alkyl, C1-C3 alkoxy, halo, Rb, and (CH2)tNRaRa optionally substituted with dimethylamino;
• R4 is selected from the group consisting of:
• C1-C3 alkyl optionally substituted with cycloalkyl,
• C3-C5 cycloalkyl,
• Rb optionally substituted with one or more substituents selected from the group consisting of:
• 1) C1-C3 alkyl, 2) halo, 3) (CH2)vNRaRa, 4) (CH2)vCF3, 5) C(O)CH3 and
• 6) benzylcarboxylate,
• Rc optionally substituted with one or more substituents selected from the group consisting of:
• 1) halo, 2) CN, 3) C1-C3 alkoxy, 4) Rb optionally substituted with C1-C3 alkyl, and 5) (CH2)vNRaRa, and
• Rd optionally substituted with one or more substituents selected from the group consisting of:
• 1) C1-C3 alkyl, 2) C1-C3 alkoxy, 3) CF3, 4) halo, and 5) Rb optionally substituted with C1-C3 alkyl;
• R5 is H, C1-C3 alkyl or halo;
• each Ra is C1-C6 alkyl, C3-C5 cycloalkyl or H;
• each Rb is heterocycloalkyl;
• each Rc is phenyl;
• each Rd is heteroaryl;
• s is 1 or 2;
• k is 2 or 3;
• m is 0, 1, 2 or 3;
• n is 0, 1, 2 or 3;
• t is 0, 1, 2 or 3;
• and
• v is 0, 1, 2 or 3.