Formulations of deoxycholic acid and salts thereof
AssigneeKythera Biopharmaceuticals, Inc.
InventorsRobert Emil Hodge, Jeffrey Douglas Webster
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Abstract
The present application is directed to an aqueous pharmaceutical formulation comprising less than about 5% w/v sodium deoxycholate maintained at a pH sufficient to substantially inhibit precipitation of the sodium deoxycholate. Also disclosed herein, are methods for inhibiting precipitation of sodium deoxycholate in an aqueous solution comprising less than about 5% w/v of sodium deoxycholate, said method comprising maintaining pH of the solution of from at least about 8.0 to about 8.5.
Claims10
1-37. (canceled)
A method for inhibiting precipitation of sodium deoxycholate in an aqueous solution to increase the shelf life of the solution, comprising preparing an aqueous solution of sodium deoxycholate and adjusting the alkalinity of the solution to be sufficient to substantially inhibit precipitation of the sodium deoxycholate, wherein the solution comprising from about 0.05% w/v to about 2% w/v sodium deoxycholate and at least one pharmaceutically acceptable excipient and/or carrier.
Dependencies are inferred from the claim text.