Method for treating lung disease
OwnerJohn W. Hollingsworth, William Michael Foster +2inventors
InventorsJohn W. Hollingsworth, William Michael Foster, Erin Potts-Kant, Zhuowei Li
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Abstract
Methods of treating lung diseases comprising administering inducers of NAD(P)H:quinone oxidoreductase 1 (NQO1) are disclosed. Inducers of NQO1 include naphthoquinones such as β-lapachone. Methods of predicting whether a subject with a lung disease will respond to treatment with a naphthoquinone are also described herein.
Claims13
A method of treating a lung disease in a subject, comprising administering to the subject an effective amount of a naphthoquinone and a bronchodilator, wherein the naphthoquinone and the bronchodilator are administered via inhalation.
-19. (canceled)
A method of predicting responsiveness of a subject with a lung disease to treatment with a naphthoquinone, comprising:
- a) detecting the level or activity of NQO1 in a sample obtained from the subject;
- and
- b) comparing the level or activity of NQO1 in the sample to a standard level, wherein an altered level or activity of NQO1 indicates that the subject is responsive to treatment with a naphthoquinone.
A method of identifying a subject with a lung disease as a candidate for treatment with a naphthoquinone, comprising:
- a) detecting the level or activity of NQO1 in a sample obtained from the subject;
- and
- b) comparing the level or activity of NQO1 in the sample to a standard level, wherein a difference in the level or activity of NQO1 indicates that the subject is a candidate for treatment with a naphthoquinone.
A method for identifying a subject as having an increased risk of developing lung disease, comprising:
- a) providing a sample from a subject;
- b) determining the presence or absence of a functional variant of NQO1 in the sample;
- and
- c) identifying the patient as having an increased risk of developing lung disease when a functional variant of NQO1 is present in the sample.
Dependencies are inferred from the claim text.