Substituted tetracycline compounds

A tetracycline compound of Formula (III):

• wherein
• R9 is R′—O—N═CR″—, R′—OC(═O)—, R9aR9bNC(═O)—, methoxycarbonyl substituted alkynyl, pyrazinyl, alkylaminocarbonylalkyl, methoxymethyl, methoxymethyl substituted alkynyl, dimethylaminocarbonyl, cyclopropyl, methyl, amino substituted pyridinyl, alkoxyalkyl, alkylcarbonyl, arylcarbonyl, pyrimidinyl, alkoxycarbonyl substituted alkynyl, oxazolyl, pyrazolyl, carboxylate, halogen, piperidinylcarbonyl, alkyoxyalkyl substituted alkynyl, pyridinyl, thiazolyl, substituted or unsubstituted arylthiocarbonyl, cyano, deuterated alkylaminoalkyl, pyrrolidonylcarbonyl, carboxylatecarbonyl, alkylcarbonyl substituted phenyl, cyano substituted pyridinyl, aminocarbonyl substituted phenyl, dialkylaminomethyl, substituted or unsubstituted thiophenyl, substituted or unsubstituted furanyl, alkylcarbonylamino substituted pyridinyl, dialkylamino substituted phenyl, carboxylate substituted phenyl, azepanylcarbonyl, or piperazinylcarbonyl;
• R10 is hydrogen or alkenyl;
• R′ is unsubstituted alkyl, amino substituted alkyl, methoxy substituted alkyl, halogen substituted alkyl;
• R″ is alkyl;
• R9a is hydrogen or alkyl;
• R9b is alkyl, hydroxyl, alkoxy, hydroxyalkyl, alkoxyalkyl, alkylcarbonylaminoalkyl, alkoxycarbonylalkyl, hydroxyalkyl, aryl, cycloalkyl or aminoalkyl;
• and pharmaceutically acceptable salts, esters and prodrugs thereof, provided that when R9 is halogen, then R10 is alkenyl.