Curable bone substitute
AssigneeA Enterprises, Inc.
InventorsArthur Ashman, Devon A. Shipp
Life of this patent
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Abstract
A novel composition, kit, and method of using the composition as a bone substitute for dental, orthopedic and drug delivery purposes. Specifically, the bone substitute comprises a plurality of polymeric beads having a crosslinkable shell where the shell is cured by light and/or chemical curing.
Claims38
A crosslinkable bone substitute material comprising micron sized particles, each particle having a core comprising one or more first biologically-compatible material(s), and
- a shell generally surrounding the core, the shell comprising one or more second biologically-compatible polymer or polymerizable material(s) having at least one crosslinkable reactive group;
- wherein the bone substitute material has interstices between the particles forming pores into which bone tissue can grow;
- and
- wherein the shell forms a crosslinked polymer upon curing by light and/or redox chemistry.
A crosslinked bone substitute comprising a matrix of micron sized particles, each particle having a core comprising one or more first biologically-compatible material(s) and a shell generally surrounding the core, the shell comprising one or more second biologically-compatible polymeric material(s);
- wherein each particle shell has at least one crosslinked moiety electrostatically or chemically bound to a crosslinked moiety of a different particle shell;
- wherein the bone substitute has interstices between the particles forming pores into which bone tissue can grow.
A method of promoting bone generation comprising the steps:
- (i) mixing a core comprising one or more first biologically-compatible material(s), a shell material comprising one or more second biologically-compatible hydrophilic polymer or polymerizable material(s) having at least one crosslinkable reactive group, and an initiator to form a crosslinkable bone substitute;
- (ii) applying the crosslinkable bone substitute to an area in need of bone generation;
- and
- (iii) crosslinking the bone substitute,
- wherein the bone substitute promotes and/or induces bone generation.
A delivery system comprising:
- (i) micron sized core particles comprising one or more first biologically-compatible material(s) and
- (ii) a shell material comprising one or more second biologically-compatible hydrophilic polymer or polymerizable material(s) having at least one crosslinkable reactive group;
- (iii) initiator component A comprising a photochemical initiator;
- and
- (iv) initiator component B comprising a photochemical accelerator.
Dependencies are inferred from the claim text.