US 2014/0155339 A1 · HYDROXYTYROSOL AND OLEUROPEIN COMPOSITIONS FOR INDUCTION OF DNA DAMAGE, CELL DEATH AND LSD1 INHIBITION

Abstract

Compositions comprising hydroxytyrosol-containing formulations and treatment regiments comprising hydroxytyrosol and/or oleuropein and chemotherapeutic agents are disclosed. Compositions and/or regiments may optionally include the administration of vitamins, minerals, and anti-oxidants. Methods for using these compositions and treatment regimens for treating subjects for diseases, such as a malignancy, and for inducing or enhancing angiogenesis, treating or preventing oxidative stress, for treating or preventing high glucose-induced dysfunction, treating or preventing chemotherapy-induced dysfunction, and for improving cell viability are provided. Various methods for use of the hydroxytyrosol compositions for inhibition of lysine specific demethylase 1 (LSD1) in various cancers are also provided.

Claims20

Dependent claims

A pharmaceutical composition for treatment, suppression and/or amelioration of a condition or disease currently treated with chemotoxic compounds, wherein said composition comprises hydroxytyrosol, a hydroxytyrosol derived and/or substituted compound, and/or a hydroxytyrosol metabolite.

A method of treating a condition of disease currently treated with chemotoxic compounds, comprising:

administering to an individual in need thereof a composition comprising hydroxytyrosol, a hydroxytyrosol derived and/or substituted compound, and/or a hydroxytyrosol metabolite selected from the group consisting of:
(a) hydroxytyrosol that is isolated, purified and/or synthesized and has the following formula:
(b) a hydroxytyrosol acyl derivative according to the following structure:
and
(c) hydroxytyrosol derived and/or substituted compound and/or hydroxytyrosol metabolite has the following formula:
wherein R1, R2, and R2 provide a pharmaceutically acceptable salt, solvate, prodrug and/or isomer of hydroxytyrosol;
wherein said hydroxytyrosol, a hydroxytyrosol derived and/or substituted compound, and/or a hydroxytyrosol metabolite has an inhibitory efficacy against the LSD1 protein.

4 more elements

A method for detecting cancer or pre-cancer cells in an individual comprising:

contacting a sample from said individual with or administering to an individual in need thereof a composition comprising hydroxytyrosol, a hydroxytyrosol derived and/or substituted compound, and/or a hydroxytyrosol metabolite to a particular site of said individual followed by detection of genetic and epigenetic effects;
and
detecting cancerous or pre-cancerous cells.

A hydroxytyrosol-based inhibitor of the LDS1 protein comprising:

hydroxytyrosol, a hydroxytyrosol derived and/or substituted compound, and/or a hydroxytyrosol metabolite.

A method of inhibiting LSD1 in a cell comprising contacting said cell with a composition comprising a compound that interacts with LSD1 at either the flavin group of LSD1 or close to the adenosine group of LSD1.

Dependencies are inferred from the claim text.

Hydroxytyrosol and oleuropein compositions for induction of dna damage, cell death and lsd1 inhibition

Life of this patent

Hydroxytyrosol and oleuropein compositions for induction of dna damage, cell death and lsd1 inhibition

Life of this patent

Abstract

Claims20