Polyphosphate and pyrophosphate derivative of saccharides
AssigneesUniversite De Strasbourg, NormOxys, Inc.
InventorsJean-Marie Lehn, Yves Claude Nicolau, Rajamalleswaramma Jogireddy, Adam H. Brockman, John Hey, Yongxin Yu
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Abstract
The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery.
Claims41
A pharmaceutical composition comprising a compound that is a polyphosphate or pyrophosphate derivative of a mono-, di- or oligosaccharide containing a pyranose or furanose unit, or a pharmaceutically acceptable salt thereof.
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A compound of Formula I
- wherein:
- R1 and R10 are independently H, C1-C6 alkyl, C1-C6 haloalkyl, aryl C1-C6 alkyl, phosphate, polyphosphate,
- R2 is H;
- R3, R4, R5, R6, R7, R8, R9, and R10 are independently H, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, C1-C6 haloalkyl, aryl C1-C6 alkyl, phosphate, polyphosphate;
- and
- R11, R12, R13, R14, R15, R16, R17, R18, and R19 are independently H, OH, phosphate, or polyphosphate;
- wherein at least one of R1 to R10 are phosphate or polyphosphate;
- or a pharmaceutical acceptable salt, stereoisomer, anomer, solvate, and hydrate thereof.
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A compound of Formula II:
- wherein:
- R1 is H, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, C1-C6 haloalkyl, aryl C1-C6 alkyl, phosphate, or polyphosphate;
- and
- R2 is H
- or a pharmaceutical acceptable salt, stereoisomer, anomer, solvate, and hydrate thereof.
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Dependencies are inferred from the claim text.