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US 2014/0155330 A1Published application
Compositions And Methods For Modulating Apoptosis
AssigneeYeda Research and Development Co. Ltd.
InventorsAdi Kimchi, Assaf Rubinstein
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Abstract
Peptides, compositions and methods for modulating apoptosis, useful for treating diseases or disorders characterized by dysregulated apoptosis, such as cancer or neurodegenerative diseases. Screening methods for identifying agents that mediate apoptosis by regulating Atg12 binding to Bcl-2 family members.
Claims27
An isolated peptide comprising an amino acid sequence having no more than 30 amino acids as set forth in SEQ ID NO:
- 1 (IDILLKAVGDTP), or an analog or derivative thereof.
A method of screening for a pro-apoptotic agent, the method comprising the steps of:
- exposing a cell expressing Atg12 and a Bcl-2 anti-apoptotic protein to a putative pro-apoptotic agent;
- and
- determining the binding of Atg12 to the Bcl-2 anti-apoptotic protein;
- wherein enhancement of said binding indicates that the agent is a pro-apoptotic agent.
1 more element
A method of screening for an anti-apoptotic agent, the method comprising the steps of:
- exposing a cell expressing Atg12 and a Bcl-2 anti-apoptotic protein to a putative anti-apoptotic agent;
- and
- determining the binding of Atg12 to the Bcl-2 anti-apoptotic protein;
- wherein reduction of said binding indicates that the agent is an anti-apoptotic agent.
1 more element
Dependencies are inferred from the claim text.