Polypeptides, nucleic acid molecule encoding polypeptides, and uses of polypeptides
AssigneeChina Medical University
InventorsTin-Yun HO, Chien-Yun HSIANG
Life of this patent
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Abstract
A polypeptide, a nucleic acid molecule encoding the polypeptide and a pharmaceutical composition comprising the polypeptide are provided. The polypeptide is as defined in the description, can bind to insulin receptors, and is effective in reducing blood sugar, reducing glycated hemoglobin, and ameliorating hepato-renal disorders caused by diabetes.
Claims14
An isolated polypeptide consisting of the segmental amino acid sequence of SEQ ID NO:1 selected from the group consisting of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO:6.
An isolated polypeptide consisting of the amino acid sequence selected from the group consisting of SEQ ID NO:179, SEQ ID NO:180, SEQ ID NO:181, SEQ ID NO:182, SEQ ID NO:183, SEQ ID NO:184, SEQ ID NO:185, SEQ ID NO:186, SEQ ID NO:187, and SEQ ID NO:188.
An isolated polypeptide consisting of the amino acid sequence of RYKYQX1X2YI (SEQ ID NO:
- 189) or a homologous amino acid sequence derived from the substitution of a single amino acid in SEQ ID NO:
- 189, wherein X1 is cysteine or tryptophan and X2 is phenylalanine or tryptophan.
Dependencies are inferred from the claim text.