Antimicrobial compositions and methods of use thereof

A method of treating a microbial infection, comprising:

• administering to a subject in need thereof an effective amount of an antimicrobial peptide comprising a first antimicrobial domain comprising two SEQ ID NO:
• 1 motifs, or two SEQ ID NO:
• 2 motifs, or one SEQ ID NO:
• 1 motif and two SEQ ID NO:
• 2 motif.

A method of treating a microbial infection, comprising:

• administering to a subject in need of such treatment an effective amount of an expression vector capable of expressing an antimicrobial peptide,
• wherein said antimicrobial peptide comprises a first antimicrobial domain comprising two SEQ ID NO:
• 1 motifs, or two SEQ ID NO:
• 2 motifs, or one SEQ ID NO:
• 1 motif and two SEQ ID NO:
• 2 motif.

A pharmaceutical composition for treating microbial infection, comprising:

• (1) an antimicrobial peptide comprising
• an antimicrobial domain comprising two SEQ ID NO:
• 1 motifs, or two SEQ ID NO:
• 2 motifs, or one SEQ ID NO:
• 1 motif and two SEQ ID NO:
• 2 motif;
• and
• a cell penetrating peptide (CPP) domain and/or a targeting domain;
• and
• (2) a pharmaceutically acceptable carrier.