Peptides and compositions for prevention of cell adhesion and methods of using same
AssigneeTel HaShomer Medical Research Infrastructure and Services Ltd.
InventorAmir ZLOTKIN
Life of this patent
Estimating the term…
Abstract
Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2), SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3) or CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.
Claims19
A peptide having a sequence selected from the group consisting of FDYDWY, SFDYDWY, SFDYDWYN, HSFDYDWYN, HSFDYDWYNV, VHSFDYDWYNV, VHSFDYDWYNVS, SVHSFDYDWYNVS, SVHSFDYDWYNVSD, KSVHSFDYDWYNVSD, KSVHSFDYDWYNVSDQ, NKSVHSFDYDWYNVSDQ, NKSVHSFDYDWYNVSDQA, QNKSVHSFDYDWYNVSDQA, QNKSVHSFDYDWYNVSDQAD, SQNKSVHSFDYDWYNVSDQAD, SQNKSVHSFDYDWYNVSDQADL, FSQNKSVHSFDYDWYNVSDQADL, FSQNKSVHSFDYDWYNVSDQADLK, SFSQNKSVHSFDYDWYNVSDQADLK, SFSQNKSVHSFDYDWYNVSDQADLKN, CSFSQNKSVHSFDYDWYNVSDQADLKN, CSFSQNKSVHSFDYDWYNVSDQADLKNC, and FNFDWY or combinations thereof.
A composition comprising a peptide isolated from an animal source, said peptide comprising a sequence selected from the group consisting of FDYDWY, SFDYDWY, SFDYDWYN, HSFDYDWYN, HSFDYDWYNV, VHSFDYDWYNV, VHSFDYDWYNVS, SVHSFDYDWYNVS, SVHSFDYDWYNVSD, KSVHSFDYDWYNVSD, KSVHSFDYDWYNVSDQ, NKSVHSFDYDWYNVSDQ, NKSVHSFDYDWYNVSDQA, QNKSVHSFDYDWYNVSDQA, QNKSVHSFDYDWYNVSDQAD, SQNKSVHSFDYDWYNVSDQAD, SQNKSVHSFDYDWYNVSDQADL, FSQNKSVHSFDYDWYNVSDQADL, FSQNKSVHSFDYDWYNVSDQADLK, SFSQNKSVHSFDYDWYNVSDQADLK, SFSQNKSVHSFDYDWYNVSDQADLKN, CSFSQNKSVHSFDYDWYNVSDQADLKN, CSFSQNKSVHSFDYDWYNVSDQADLKNC, and FNFDWY, or a combination thereof.
A method of preventing adhesion of a single cell organism to a surface, the method comprising contacting the cell with a composition comprising a peptide isolated from an animal source, said peptide comprising a sequence selected from the group consisting FDYDWY, SFSQNKSVHSFDYDWYNVSDQADLKN or CSFSQNKSVHSFDYDWYNVSDQADLKNC.
Dependencies are inferred from the claim text.