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US 2014/0155313 A1Published application
Hydrogels with covalently linked polypeptides
AssigneeSusavion Biosciences, Inc.
InventorsLaura L. Eggink, J. Kenneth Hoober
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Abstract
The present invention provides methods of synthesizing hydrogels that contain covalently linked polypeptides. These polypeptides may be tetravalent peptides or polypeptides that bind to cell surface receptors. The hydrogels synthesized by the methods of the present invention may be used in wound dressings or applied directly to wounds to promote healing.
Claims19
A composition comprising an acrylate polymeric scaffold covalently linked to a compound represented by formula (II):
- wherein
- X1 is a linker selected from the group consisting of polyethylene glycol (PEG) and an amino acid sequence consisting of GGGS (SEQ ID NO:
- 1), and
- each of Q1, Q2, Q3, and Q4 is independently a therapeutic polypeptide.
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A method of synthesizing a hydrogel comprising:
- (a) reacting a C-terminal cysteine sulfhydryl group of a first peptide polymer with a halogen on a compound represented by formula (I):
- wherein n is an integer between 1 and 6, R1 represents a halogen, and R2 represents a methyl, an ethyl, a hydroxymethyl, a hydroxyethyl, or a hydrogen;
- and
- (b) adding the first peptide polymer to a second polymer with a radical initiator to begin polymerization of the hydrogel.
1 more element
Dependencies are inferred from the claim text.