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US 2014/0155293 A1Published application
Identification of biomarkers for detecting prostate cancer
AssigneeThe Johns Hopkins University
InventorsDaniel W. Chan, Jinong Li, Zhen Zhang
Life of this patent
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Abstract
The present invention relates to a method of qualifying prostate cancer status in a subject comprising: (a) measuring at least one of the disclosed biomarkers in a sample from the subject and (b) correlating the measurement with prostate cancer status. The invention further relates to kits for qualifying prostate cancer status in a subject.
Claims19
A method of qualifying prostate cancer status in a subject comprising:
- (a) measuring at least one biomarker in a sample from the subject, wherein the biomarker is selected from the group consisting of
- Marker I:
- having a molecular weight of about 7.808 kD
- Marker II:
- having a molecular weight of about 14.576 kD
- Marker III:
- having a molecular weight of about 2.062 kD
- Marker IV:
- having a molecular weight of about 7.974 kD
- Marker V:
- having a molecular weight of about 6.677 kD
- Marker VI:
- having a molecular weight of about 3.936 kD
- Marker VII:
- having a molecular weight of about 60.958 kD
- Marker VIII:
- having a molecular weight of about 5.149 kD
- Marker IX:
- having a molecular weight of about 5.861 kD
- Marker X:
- having a molecular weight of about 28.098 kD
- Marker XI:
- having a molecular weight of about 2.996 kD
- Marker XII:
- having a molecular weight of about 24.346 kD
- Marker XIII:
- having a molecular weight of about 6.722 kD
- Marker XIV:
- having a molecular weight of about 5.999 kD
- Marker XV:
- having a molecular weight of about 6.158 kD
- Marker XVI:
- having a molecular weight of about 55.785 kD
- Marker XVII:
- having a molecular weight of about 2.540 kD
- Marker XVIII:
- having a molecular weight of about 8.019 kD
- Marker XIX:
- having a molecular weight of about 4.658 kD
- Marker XX:
- having a molecular weight of about 14.703 kD
- Marker XXI:
- having a molecular weight of about 2.68 kD
- Marker XXII:
- having a molecular weight of about 3.16 kD
- Marker XXIII:
- having a molecular weight of about 10.3 kD
- Marker XXIV:
- having a molecular weight of about 10.8 kD
- Marker XXV:
- having a molecular weight of about 12.7 kD
- Marker XXVI:
- having a molecular weight of about 17.9 kD
- Marker XXVII:
- having a molecular weight of about 2.79 kD
- Marker XXVIII:
- having a molecular weight of about 3.32 kD
- Marker XXIX:
- having a molecular weight of about 4.29 kD
- Marker XXX:
- having a molecular weight of about 15.9 kD
- Marker XXXI:
- having a molecular weight of about 16.1 kD
- Marker XXXII:
- having a molecular weight of about 16.3 kD, and
- combinations thereof, and
- (b) correlating the measurement with prostate cancer status.
64 more elements
A method for differentiating between a diagnosis of prostate cancer and non-prostate cancer comprising:
- (a) detecting in a subject sample an amount of at least one biomarker selected from the group consisting of:
- Marker I:
- having a molecular weight of about 7.808 kD
- Marker II:
- having a molecular weight of about 14.576 kD
- Marker III:
- having a molecular weight of about 2.061 kD
- Marker IV:
- having a molecular weight of about 7.973 kD
- Marker V:
- having a molecular weight of about 6.677 kD and
- Marker VI:
- having a molecular weight of about 3.935 kD;
- and
- (b) correlating the amount with a diagnosis of prostate cancer or non-prostate cancer.
12 more elements
A method for differentiating between a diagnosis of prostate cancer and benign prostate hyperplasia comprising:
- (a) detecting in a subject sample an amount of at least one biomarker selected from the group consisting of:
- Marker VII:
- having a molecular weight of about 60.958 kD
- Marker VIII:
- having a molecular weight of about 5.148 kD
- Marker IX:
- having a molecular weight of about 5.860 kD
- Marker X:
- having a molecular weight of about 28.097 kD
- Marker XI:
- having a molecular weight of about 2.996 kD
- Marker XII:
- having a molecular weight of about 24.346 kD
- Marker XIII:
- having a molecular weight of about 6.722 kD
- Marker XIV:
- having a molecular weight of about 5.999 kD
- Marker XV:
- having a molecular weight of about 6.159 kD
- Marker XVI:
- having a molecular weight of about 55.785 kD
- (b) correlating the amount with a diagnosis of prostate cancer or benign prostate hyperplasia.
19 more elements
A method for differentiating between a diagnosis of prostate cancer and benign prostate hyperplasia comprising:
- (a) detecting in a subject sample an amount of at least one biomarker selected from the group consisting of:
- Marker XXI:
- having a molecular weight of about 2.68 kD
- Marker XXII:
- having a molecular weight of about 3.16 kD
- Marker XXIII:
- having a molecular weight of about 10.3 kD
- Marker XXIV:
- having a molecular weight of about 10.8 kD
- Marker XXV:
- having a molecular weight of about 12.7 kD, and
- Marker XXV having a molecular weight of about 17.9 kD.
- (b) correlating the amount with a diagnosis of prostate cancer or benign prostate hyperplasia.
10 more elements
A method for differentiating between a diagnosis of organ defined prostate cancer and non-organ-defined prostate cancer comprising:
- (a) detecting in a subject sample an amount of at least one biomarker selected from the group consisting of:
- Marker XVII:
- having a molecular weight of about 2.540 kD
- Marker XVII having a molecular weight of about 8.018 kD
- Marker XIX:
- having a molecular weight of about 4.658 kD,
- and
- Marker XX:
- having a molecular weight of about 14.703 kD;
- and
- (b) correlating the amount with a diagnosis of organ-defined prostate cancer or non-organ-defined prostate cancer.
8 more elements
A method for differentiating between a diagnosis of organ defined prostate cancer and non-organ-defined prostate cancer comprising:
- (a) detecting in a subject sample an amount of at least one biomarker selected from the group consisting of:
- Marker XXVII:
- having a molecular weight of about 2.79 kD
- Marker XXVIII:
- having a molecular weight of about 3.32 kD
- Marker XXIX:
- having a molecular weight of about 4.29 kD
- Marker XXX:
- having a molecular weight of about 15.9 kD
- Marker XXXI:
- having a molecular weight of about 16.1 kD, and
- Marker XXXII:
- having a molecular weight of about 16.3 kD.
- (b) correlating the amount with a diagnosis of organ-defined prostate cancer or non-organ-defined prostate cancer.
11 more elements
13-29. (canceled)
A kit for aiding the diagnosis of cancer, comprising:
- an adsorbent attached to a substrate, wherein the adsorbent retains one or more biomarkers selected from:
- Marker I:
- having a molecular weight of about 7.808 kD
- Marker II:
- having a molecular weight of about 14.576 kD
- Marker III:
- having a molecular weight of about 2.062 kD
- Marker IV:
- having a molecular weight of about 7.974 kD
- Marker V:
- having a molecular weight of about 6.677 kD
- Marker VI:
- having a molecular weight of about 3.936 kD
- Marker VII:
- having a molecular weight of about 60.958 kD
- Marker VIII:
- having a molecular weight of about 5.149 kD
- Marker IX:
- having a molecular weight of about 5.861 kD
- Marker X:
- having a molecular weight of about 28.098 kD
- Marker XI:
- having a molecular weight of about 2.996 kD
- Marker XII:
- having a molecular weight of about 24.346 kD
- Marker XIII:
- having a molecular weight of about 6.722 kD
- Marker XIV:
- having a molecular weight of about 5.999 kD
- Marker XV:
- having a molecular weight of about 6.159 kD
- Marker XVI:
- having a molecular weight of about 55.784 kD
- Marker XVII:
- having a molecular weight of about 2.540 kD
- Marker XVIII:
- having a molecular weight of about 8.019 kD
- Marker XIX:
- having a molecular weight of about 4.658 kD
- Marker XX:
- having a molecular weight of about 14.703 kD
- Marker XXI:
- having a molecular weight of about 2.68 kD
- Marker XXII:
- having a molecular weight of about 3.16 kD
- Marker XXIII:
- having a molecular weight of about 10.3 kD
- Marker XXIV:
- having a molecular weight of about 10.8 kD
- Marker XXV:
- having a molecular weight of about 12.7 kD
- Marker XXVI:
- having a molecular weight of about 17.9 kD
- Marker XXVII:
- having a molecular weight of about 2.79 kD
- Marker XXNIII:
- having a molecular weight of about 3.32 kD
- Marker XXIX:
- having a molecular weight of about 4.29 kD
- Marker XXX:
- having a molecular weight of about 15.9 kD
- Marker XXXI:
- having a molecular weight of about 16.1 kD, and
- Marker XXXII:
- having a molecular weight of about 16.3 kD.
62 more elements
32-41. (canceled)
A protein purified on a biochip selected from:
- Marker I:
- having a molecular weight of about 7.808 kD
- Marker II:
- having a molecular weight of about 14.576 kD
- Marker III:
- having a molecular weight of about 2.062 kD
- Marker IV:
- having a molecular weight of about 7.974 kD
- Marker V:
- having a molecular weight of about 6.667 kD
- Marker VI:
- having a molecular weight of about 3.936 kD
- Marker VII:
- having a molecular weight of about 60.958 kD
- Marker VIII:
- having a molecular weight of about 5.149 kD
- Marker IX:
- having a molecular weight of about 5.861 kD
- Marker X:
- having a molecular weight of about 28.098 kD
- Marker XI:
- having a molecular weight of about 2.996 kD
- Marker XII:
- having a molecular weight of about 24.346 kD
- Marker XIII:
- having a molecular weight of about 6.722 kD
- Marker XIV:
- having a molecular weight of about 5.999 kD
- Marker XV:
- having a molecular weight of about 6.159 kD
- Marker XVI:
- having a molecular weight of about 55.784 kD
- Marker XVII:
- having a molecular weight of about 2.540 kD
- Marker XVIII:
- having a molecular weight of about 8.019 kD
- Marker XIX:
- having a molecular weight of about 4.658 kD
- Marker XX:
- having a molecular weight of about 14.703 kD
- Marker XXI:
- having a molecular weight of about 2.68 kD
- Marker XXII:
- having a molecular weight of about 3.16 kD
- Marker XXIII:
- having a molecular weight of about 10.3 kD
- Marker XXIV:
- having a molecular weight of about 10.8 kD
- Marker XXV:
- having a molecular weight of about 12.7 kD
- Marker XXVI:
- having a molecular weight of about 17.9 kD
- Marker XXVII:
- having a molecular weight of about 2.79 kD
- Marker XXVIII:
- having a molecular weight of about 3.32 kD
- Marker XXIX:
- having a molecular weight of about 4.29 kD
- Marker XXX:
- having a molecular weight of about 15.9 kD
- Marker XXXI:
- having a molecular weight of about 16.1 kD, and
- Marker XXXII:
- having a molecular weight of about 16.3 Kd.
61 more elements
44-77. (canceled)
Dependencies are inferred from the claim text.